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Mar. Drugs 2011, 9(8), 1307-1318; doi:10.3390/md9081307
Article

New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum

1
, 1
, 1
, 2,*  and 1,3,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Center for Asia-Pacific Ocean Research and Translational Biopharmaceuticals, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Authors to whom correspondence should be addressed.
Received: 4 July 2011 / Revised: 13 July 2011 / Accepted: 22 July 2011 / Published: 27 July 2011
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Abstract

Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M–Q (15). The structures of compounds 15 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED50 of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC50 of 5.2 μg/mL.
Keywords: soft coral; Lobophytum durum; cytotoxicity; antiviral activity soft coral; Lobophytum durum; cytotoxicity; antiviral activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cheng, S.-Y.; Chen, P.-W.; Chen, H.-P.; Wang, S.-K.; Duh, C.-Y. New Cembranolides from the Dongsha Atoll Soft Coral Lobophytum durum. Mar. Drugs 2011, 9, 1307-1318.

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