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• Reid, E
• Worthy, C
• Probert, I
• Ali, S
• Love, J
• Napier, J
• Littlechild, J
• Somerfield, P
• Allen, M
• [+] on Google Scholar
• Reid, E
• Worthy, C
• Probert, I
• Ali, S
• Love, J
• Napier, J
• Littlechild, J
• Somerfield, P
• Allen, M
• [+] on PubMed
• Reid, E
• Worthy, C
• Probert, I
• Ali, S
• Love, J
• Napier, J
• Littlechild, J
• Somerfield, P
• Allen, M

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Mar. Drugs 2011, 9(4), 586-602; doi:10.3390/md9040586

Article

Coccolithophores: Functional Biodiversity, Enzymes and Bioprospecting

Emma L. Reid ^1,2 , Charlotte A. Worthy ^1,3 , Ian Probert ⁴ , Sohail T. Ali ¹ , John Love ² , Johnathan Napier ³ , Jenny A. Littlechild ² , Paul J. Somerfield ¹  and Michael J. Allen ^1,*

¹ Plymouth Marine Laboratory, Prospect Place, The Hoe, Plymouth, PL1 3DH, UK ² College of Life and Environmental Science, Biosciences, University of Exeter, Exeter, EX4 4QD, UK ³ Department of Biological Chemistry, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK ⁴ CNRS-UPMC Station Biologique de Roscoff, Place Georges Teissier, 29682 Roscoff Cedex, France

* Author to whom correspondence should be addressed.

Received: 15 March 2011; in revised form: 1 April 2011 / Accepted: 7 April 2011 / Published: 11 April 2011

(This article belongs to the Special Issue Enzymes from the Sea: Sources, Molecular Biology and Bioprocesses)

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Abstract: Emiliania huxleyi is a single celled, marine phytoplankton with global distribution. As a key species for global biogeochemical cycling, a variety of strains have been amassed in various culture collections. Using a library consisting of 52 strains of E. huxleyi and an ‘in house‘ enzyme screening program, we have assessed the functional biodiversity within this species of fundamental importance to global biogeochemical cycling, whilst at the same time determining their potential for exploitation in biocatalytic applications. Here, we describe the screening of E. huxleyi strains, as well as a coccolithovirus infected strain, for commercially relevant biocatalytic enzymes such as acid/alkali phosphodiesterase, acid/alkali phosphomonoesterase, EC1.1.1-type dehydrogenase, EC1.3.1-type dehydrogenase and carboxylesterase.

Keywords: functional biodiversity; bioprospecting; biocatalysis; coccolithophore

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