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Mar. Drugs 2011, 9(4), 535-542; doi:10.3390/md9040535

Effects of High Salt Stress on Secondary Metabolite Production in the Marine-Derived Fungus Spicaria elegans

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
* Author to whom correspondence should be addressed.
Received: 23 February 2011 / Revised: 11 March 2011 / Accepted: 30 March 2011 / Published: 31 March 2011
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To obtain structurally novel and bioactive natural compounds from marine-derived microorganisms, the effect of high salt stress on secondary metabolite production in the marine-derived fungal strain, Spicaria elegans KLA-03, was investigated. The organism, which was isolated from marine sediment, produced different secondary metabolites when cultured in 3% and 10% saline conditions. Four characteristic metabolites, only produced in the 10% salinity culture, were isolated, and their structures were identified as (2E,2'Z)-3,3'-(6,6'-dihydroxybiphenyl-3,3'-diyl)diacrylic acid (1), aspulvinone E (2), aspochalasin E (3) and trichodermamide B (6), according to their 1D and 2D NMR spectra. Compound 1 is a new compound. High salt stress may therefore be a promising means to induce the production of new and chlorinated compounds in halotolerant fungi. Compound 1 showed moderate antibacterial activity against Pseudomonas aeruginosa and Escherichia coli with minimum inhibitory concentration (MIC) values of 0.038 and 0.767 mM, respectively.
Keywords: Spicaria elegans; high salt stress; secondary metabolites Spicaria elegans; high salt stress; secondary metabolites
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, Y.; Lu, Z.; Sun, K.; Zhu, W. Effects of High Salt Stress on Secondary Metabolite Production in the Marine-Derived Fungus Spicaria elegans. Mar. Drugs 2011, 9, 535-542.

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