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Mar. Drugs 2011, 9(3), 334-344; doi:10.3390/md9030334

Cytotoxic and Antimicrobial Activity of Pseudopterosins and seco-Pseudopterosins Isolated from the Octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia Islands (Southwest Caribbean Sea)

1
Departamento de Química, Universidad Nacional de Colombia, Cra. 30 N° 45-03, Bogotá D.C., Colombia
2
Departamento de Farmacia, Universidad Nacional de Colombia, Cra. 30 N° 45-03, Bogotá D.C., Colombia
3
Departments of Chemistry and Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, C1A 4P3, Charlottetown, PEI, Canada
*
Authors to whom correspondence should be addressed.
Received: 8 February 2011 / Revised: 24 February 2011 / Accepted: 25 February 2011 / Published: 4 March 2011
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Abstract

To expand the potential of pseudopterosins and seco-pseudopterosins isolated from the octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia islands (southwest Caribbean Sea), we report the anti-microbial profile against four pathogenic microorganisms (Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Candida albicans) and report a more complete cytotoxic profile against five human cells lines (HeLa, PC-3, HCT116, MCF-7 and BJ) for the compounds PsG, PsP, PsQ, PsS, PsT, PsU, 3-O-acetyl-PsU, seco-PsJ, seco-PsK and IMNGD. For the cytotoxic profiles, all compounds evaluated showed moderate and non-selective activity against both tumor and normal cell lines, where PsQ and PsG were the most active compounds (GI50 values between 5.8 µM to 12.0 µM). With respect to their anti-microbial activity the compounds showed good and selective activity against the Gram-positive bacteria, while they did not show activity against the Gram-negative bacterium or yeast. PsU, PsQ, PsS, seco-PsK and PsG were the most active compounds (IC50 2.9–4.5 µM) against S. aureus and PsG, PsU and seco-PsK showed good activity (IC50 3.1–3.8 µM) against E. faecalis, comparable to the reference drug vancomycin (4.2 µM). View Full-Text
Keywords: marine natural products; pseudopterosins; seco-pseudopterosins; Pseudopterogorgia elisabethae; cytotoxic activity; antimicrobial activity marine natural products; pseudopterosins; seco-pseudopterosins; Pseudopterogorgia elisabethae; cytotoxic activity; antimicrobial activity
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MDPI and ACS Style

Correa, H.; Aristizabal, F.; Duque, C.; Kerr, R. Cytotoxic and Antimicrobial Activity of Pseudopterosins and seco-Pseudopterosins Isolated from the Octocoral Pseudopterogorgia elisabethae of San Andrés and Providencia Islands (Southwest Caribbean Sea). Mar. Drugs 2011, 9, 334-344.

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