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Mar. Drugs 2011, 9(12), 2705-2716; doi:10.3390/md9122705

Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum

2,,*  and 1,3,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Authors to whom correspondence should be addressed.
Received: 3 November 2011 / Revised: 5 December 2011 / Accepted: 9 December 2011 / Published: 15 December 2011
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Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A–C (13) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 14 were evaluated in vitro. Compound 4 exhibited cytotoxicity against A-549 (human lung carcinoma) cell line with an ED50 of 3.6 μg/mL.
Keywords: soft coral; Lobophytum crassum; cytotoxicity soft coral; Lobophytum crassum; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lin, S.-T.; Wang, S.-K.; Duh, C.-Y. Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum. Mar. Drugs 2011, 9, 2705-2716.

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