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Mar. Drugs 2011, 9(12), 2705-2716; doi:10.3390/md9122705

Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum

2,,*  and 1,3,*
1 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 2 Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan 3 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Authors to whom correspondence should be addressed.
Received: 3 November 2011 / Revised: 5 December 2011 / Accepted: 9 December 2011 / Published: 15 December 2011
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Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A–C (13) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 14 were evaluated in vitro. Compound 4 exhibited cytotoxicity against A-549 (human lung carcinoma) cell line with an ED50 of 3.6 μg/mL.
Keywords: soft coral; Lobophytum crassum; cytotoxicity soft coral; Lobophytum crassum; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lin, S.-T.; Wang, S.-K.; Duh, C.-Y. Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum. Mar. Drugs 2011, 9, 2705-2716.

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