Mar. Drugs 2011, 9(12), 2705-2716; doi:10.3390/md9122705
Article

Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum

1email, 2,,* email and 1,3,* email
Received: 3 November 2011; in revised form: 5 December 2011 / Accepted: 9 December 2011 / Published: 15 December 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Chemical investigation of the Dongsha Atoll soft coral Lobophytum crassum has afforded four new cembranoids, crassumols A–C (13) and 13-acetoxysarcophytoxide (4). The structures of these isolated compounds were elucidated by extensive NMR and HRESIMS experiments. The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 14 were evaluated in vitro. Compound 4 exhibited cytotoxicity against A-549 (human lung carcinoma) cell line with an ED50 of 3.6 μg/mL.
Keywords: soft coral; Lobophytum crassum; cytotoxicity
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MDPI and ACS Style

Lin, S.-T.; Wang, S.-K.; Duh, C.-Y. Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum. Mar. Drugs 2011, 9, 2705-2716.

AMA Style

Lin S-T, Wang S-K, Duh C-Y. Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum. Marine Drugs. 2011; 9(12):2705-2716.

Chicago/Turabian Style

Lin, Shih-Tseng; Wang, Shang-Kwei; Duh, Chang-Yih. 2011. "Cembranoids from the Dongsha Atoll Soft Coral Lobophytum crassum." Mar. Drugs 9, no. 12: 2705-2716.


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