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Mar. Drugs 2011, 9(12), 2526-2536; doi:10.3390/md9122526

Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum

1 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 2 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
* Author to whom correspondence should be addressed.
Received: 9 November 2011 / Revised: 25 November 2011 / Accepted: 28 November 2011 / Published: 7 December 2011
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Three new cembranoids, culobophylins A–C (13), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety with an epoxide group. Compound 1 exhibited significant cytotoxic activity against HL60 and DLD-1 cancer cell lines.
Keywords: soft coral; Lobophytum crassum; cembranoids soft coral; Lobophytum crassum; cembranoids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Lee, N.-L.; Su, J.-H. Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum. Mar. Drugs 2011, 9, 2526-2536.

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