Next Article in Journal
Inhibition of Virulence Gene Expression in Staphylococcus aureus by Novel Depsipeptides from a Marine Photobacterium
Previous Article in Journal
Seaweed Polysaccharides and Derived Oligosaccharides Stimulate Defense Responses and Protection Against Pathogens in Plants
Mar. Drugs 2011, 9(12), 2526-2536; doi:10.3390/md9122526

Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum

1 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 2 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
* Author to whom correspondence should be addressed.
Received: 9 November 2011 / Revised: 25 November 2011 / Accepted: 28 November 2011 / Published: 7 December 2011
View Full-Text   |   Download PDF [890 KB, uploaded 24 February 2015]   |  


Three new cembranoids, culobophylins A–C (13), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety with an epoxide group. Compound 1 exhibited significant cytotoxic activity against HL60 and DLD-1 cancer cell lines.
Keywords: soft coral; Lobophytum crassum; cembranoids soft coral; Lobophytum crassum; cembranoids
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Supplementary material


Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Lee, N.-L.; Su, J.-H. Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum. Mar. Drugs 2011, 9, 2526-2536.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert