Mar. Drugs 2011, 9(12), 2526-2536; doi:10.3390/md9122526
Article

Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum

Nai-Lun Lee 1,2 email and Jui-Hsin Su 1,2,* email
1 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 2 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
* Author to whom correspondence should be addressed.
Received: 9 November 2011; in revised form: 25 November 2011 / Accepted: 28 November 2011 / Published: 7 December 2011
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Abstract: Three new cembranoids, culobophylins A–C (1–3), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety with an epoxide group. Compound 1 exhibited significant cytotoxic activity against HL60 and DLD-1 cancer cell lines.
Keywords: soft coral; Lobophytum crassum; cembranoids

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Cite This Article

MDPI and ACS Style

Lee, N.-L.; Su, J.-H. Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum. Mar. Drugs 2011, 9, 2526-2536.

AMA Style

Lee N-L, Su J-H. Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum. Marine Drugs. 2011; 9(12):2526-2536.

Chicago/Turabian Style

Lee, Nai-Lun; Su, Jui-Hsin. 2011. "Tetrahydrofuran Cembranoids from the Cultured Soft Coral Lobophytum crassum." Mar. Drugs 9, no. 12: 2526-2536.

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