Next Article in Journal / Special Issue
Analytical Challenges: Determination of Tetrodotoxin in Human Urine and Plasma by LC-MS/MS
Previous Article in Journal
Tasco®, a Product of Ascophyllum nodosum, Imparts Thermal Stress Tolerance in Caenorhabditis elegans
Previous Article in Special Issue
The Chemical Synthesis of Tetrodoxin: An Ongoing Quest
Article Menu

Export Article

Open AccessReview
Mar. Drugs 2011, 9(11), 2283-2290; doi:10.3390/md9112283

Gustatory Detection of Tetrodotoxin and Saxitoxin, and Its Competitive Inhibition by Quinine and Strychnine in Freshwater Fishes

Department of Biological Sciences, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada
Received: 19 September 2011 / Revised: 31 October 2011 / Accepted: 1 November 2011 / Published: 8 November 2011
(This article belongs to the Special Issue Tetrodotoxin)
View Full-Text   |   Download PDF [563 KB, uploaded 24 February 2015]   |  

Abstract

Fish detect extremely low levels of marine toxins tetrodotoxin (TTX) and saxitoxin (STX) via the specialized gustatory receptor(s). Physiological and pharmacological studies show that receptor(s) for TTX and STX are distinct from those which detect feeding stimulant amino acids and bile acids, and that TTX and STX do not share the same receptor populations, while interacting with quinine and strychnine in a competitive fashion suggestive of an antidotal relationship. View Full-Text
Keywords: fish; gustation; tertrodotoxin; quinine; strychnine; inhibition; antidote fish; gustation; tertrodotoxin; quinine; strychnine; inhibition; antidote
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hara, T.J. Gustatory Detection of Tetrodotoxin and Saxitoxin, and Its Competitive Inhibition by Quinine and Strychnine in Freshwater Fishes. Mar. Drugs 2011, 9, 2283-2290.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top