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Mar. Drugs 2011, 9(11), 2283-2290; doi:10.3390/md9112283
Review

Gustatory Detection of Tetrodotoxin and Saxitoxin, and Its Competitive Inhibition by Quinine and Strychnine in Freshwater Fishes

Received: 19 September 2011 / Revised: 31 October 2011 / Accepted: 1 November 2011 / Published: 8 November 2011
(This article belongs to the Special Issue Tetrodotoxin)
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Abstract

Fish detect extremely low levels of marine toxins tetrodotoxin (TTX) and saxitoxin (STX) via the specialized gustatory receptor(s). Physiological and pharmacological studies show that receptor(s) for TTX and STX are distinct from those which detect feeding stimulant amino acids and bile acids, and that TTX and STX do not share the same receptor populations, while interacting with quinine and strychnine in a competitive fashion suggestive of an antidotal relationship.
Keywords: fish; gustation; tertrodotoxin; quinine; strychnine; inhibition; antidote fish; gustation; tertrodotoxin; quinine; strychnine; inhibition; antidote
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hara, T.J. Gustatory Detection of Tetrodotoxin and Saxitoxin, and Its Competitive Inhibition by Quinine and Strychnine in Freshwater Fishes. Mar. Drugs 2011, 9, 2283-2290.

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