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New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation
University Institute for Bio-Organic Chemistry “Antonio González” (IUBO), University of La Laguna (ULL), Astrofísico Francisco Sánchez 2, La Laguna, Tenerife 38206, Spain
Institute of Molecular and Cellular Biology of Cancer, Cancer Research Center, CSIC-University of Salamanca, Campus Miguel de Unamuno, Salamanca E-37007, Spain
APOINTECH, Spanish-Portuguese Center for Agriculture Research (CIALE), Scientific Park of the University of Salamanca, C/Rio Duero 12, Villamayor, Salamanca E-37185, Spain
* Authors to whom correspondence should be addressed.
Received: 22 August 2011; in revised form: 24 October 2011 / Accepted: 27 October 2011 / Published: 7 November 2011
Abstract: The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)-dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.
Keywords: Laurencia viridis; squalene; polyethers; cytotoxic activity
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Pacheco, F.C.; Villa-Pulgarin, J.A.; Mollinedo, F.; Martín, M.N.; Fernández, J.J.; Daranas, A.H. New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation. Mar. Drugs 2011, 9, 2220-2235.
Pacheco FC, Villa-Pulgarin JA, Mollinedo F, Martín MN, Fernández JJ, Daranas AH. New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation. Marine Drugs. 2011; 9(11):2220-2235.
Pacheco, Francisco Cen; Villa-Pulgarin, Janny A.; Mollinedo, Faustino; Martín, Manuel Norte; Fernández, José Javier; Daranas, Antonio Hernández. 2011. "New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation." Mar. Drugs 9, no. 11: 2220-2235.