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Mar. Drugs 2011, 9(11), 2220-2235; doi:10.3390/md9112220

New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation

1,* , 1,*  and 1,*
1 University Institute for Bio-Organic Chemistry “Antonio González” (IUBO), University of La Laguna (ULL), Astrofísico Francisco Sánchez 2, La Laguna, Tenerife 38206, Spain 2 Institute of Molecular and Cellular Biology of Cancer, Cancer Research Center, CSIC-University of Salamanca, Campus Miguel de Unamuno, Salamanca E-37007, Spain 3 APOINTECH, Spanish-Portuguese Center for Agriculture Research (CIALE), Scientific Park of the University of Salamanca, C/Rio Duero 12, Villamayor, Salamanca E-37185, Spain
* Authors to whom correspondence should be addressed.
Received: 22 August 2011 / Revised: 24 October 2011 / Accepted: 27 October 2011 / Published: 7 November 2011
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The red seaweed Laurencia viridis is a rich source of secondary metabolites derived from squalene. New polyethers, such as iubol (2), 22-hydroxy-15(28)-dehydrovenustatriol (3), 1,2-dehydropseudodehydrothyrsiferol (4), and secodehydrothyrsiferol (5) have been isolated and characterized from this alga. The structures were determined through the interpretation of NMR spectroscopic data and the relative configuration was proposed on the basis of NOESY spectrum and biogenetic considerations. All new compounds exhibited significant cytotoxic activity against a panel of cancer cell lines.
Keywords: Laurencia viridis; squalene; polyethers; cytotoxic activity Laurencia viridis; squalene; polyethers; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Pacheco, F.C.; Villa-Pulgarin, J.A.; Mollinedo, F.; Martín, M.N.; Fernández, J.J.; Daranas, A.H. New Polyether Triterpenoids from Laurencia viridis and Their Biological Evaluation. Mar. Drugs 2011, 9, 2220-2235.

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