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Mar. Drugs 2011, 9(10), 1840-1859; doi:10.3390/md9101840
Review

Antitumor Peptides from Marine Organisms

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2,3,*  and 1,*
1 Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China 2 Department of Pharmacology, Capital Medical University, Beijing 100069, China 3 Institute of Oceanology, Chinese Academy of Science, Qingdao 266071, China
* Authors to whom correspondence should be addressed.
Received: 12 July 2011 / Revised: 8 September 2011 / Accepted: 22 September 2011 / Published: 10 October 2011
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Abstract

The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new antitumor agents in the field of the development of marine bioactive substances. In this review, the progress on studies of antitumor peptides from marine sources is provided. The biological properties and mechanisms of action of different marine peptides are described; information about their molecular diversity is also presented. Novel peptides that induce apoptosis signal pathway, affect the tubulin-microtubule equilibrium and inhibit angiogenesis are presented in association with their pharmacological properties. It is intended to provide useful information for further research in the fields of marine antitumor peptides.
Keywords: antitumor; peptides; marine organisms antitumor; peptides; marine organisms
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zheng, L.-H.; Wang, Y.-J.; Sheng, J.; Wang, F.; Zheng, Y.; Lin, X.-K.; Sun, M. Antitumor Peptides from Marine Organisms. Mar. Drugs 2011, 9, 1840-1859.

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