Abstract: The biodiversity of the marine environment and the associated chemical diversity constitute a practically unlimited resource of new antitumor agents in the field of the development of marine bioactive substances. In this review, the progress on studies of antitumor peptides from marine sources is provided. The biological properties and mechanisms of action of different marine peptides are described; information about their molecular diversity is also presented. Novel peptides that induce apoptosis signal pathway, affect the tubulin-microtubule equilibrium and inhibit angiogenesis are presented in association with their pharmacological properties. It is intended to provide useful information for further research in the fields of marine antitumor peptides.
Keywords: antitumor; peptides; marine organisms
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Zheng, L.-H.; Wang, Y.-J.; Sheng, J.; Wang, F.; Zheng, Y.; Lin, X.-K.; Sun, M. Antitumor Peptides from Marine Organisms. Mar. Drugs 2011, 9, 1840-1859.
Zheng L-H, Wang Y-J, Sheng J, Wang F, Zheng Y, Lin X-K, Sun M. Antitumor Peptides from Marine Organisms. Marine Drugs. 2011; 9(10):1840-1859.
Zheng, Lan-Hong; Wang, Yue-Jun; Sheng, Jun; Wang, Fang; Zheng, Yuan; Lin, Xiu-Kun; Sun, Mi. 2011. "Antitumor Peptides from Marine Organisms." Mar. Drugs 9, no. 10: 1840-1859.