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Polyhydroxylated Steroids from the Bamboo Coral Isis hippuris
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Centers for Asia-Pacific Ocean Research and Translational Biopharmaceuticals, National Sun Yat-sen University, Kaohsiung 804, Taiwan
* Authors to whom correspondence should be addressed.
Received: 25 August 2011; in revised form: 24 September 2011 / Accepted: 30 September 2011 / Published: 10 October 2011
Abstract: In previous studies on the secondary metabolites of the Taiwanese octocoral Isis hippuris, specimens have always been collected at Green Island. In the course of our studies on bioactive compounds from marine organisms, the acetone-solubles of the Taiwanese octocoral I. hippuris collected at Orchid Island have led to the isolation of five new polyoxygenated steroids: hipposterone M–O (1–3), hipposterol G (4) and hippuristeroketal A (5). The structures of these compounds were determined on the basis of their spectroscopic and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–5 and their cytotoxicity against selected cell lines were evaluated. Compound 2 exhibited inhibitory activity against HCMV, with an EC50 value of 6.0 μg/mL.
Keywords: octocoral; Isis hippuris; anti-HCMV activity
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Chen, W.-H.; Wang, S.-K.; Duh, C.-Y. Polyhydroxylated Steroids from the Bamboo Coral Isis hippuris. Mar. Drugs 2011, 9, 1829-1839.
Chen W-H, Wang S-K, Duh C-Y. Polyhydroxylated Steroids from the Bamboo Coral Isis hippuris. Marine Drugs. 2011; 9(10):1829-1839.
Chen, Wei-Hua; Wang, Shang-Kwei; Duh, Chang-Yih. 2011. "Polyhydroxylated Steroids from the Bamboo Coral Isis hippuris." Mar. Drugs 9, no. 10: 1829-1839.