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Polyhydroxylated Steroids from the Bamboo Coral Isis hippuris
AbstractIn previous studies on the secondary metabolites of the Taiwanese octocoral Isis hippuris, specimens have always been collected at Green Island. In the course of our studies on bioactive compounds from marine organisms, the acetone-solubles of the Taiwanese octocoral I. hippuris collected at Orchid Island have led to the isolation of five new polyoxygenated steroids: hipposterone M–O (1–3), hipposterol G (4) and hippuristeroketal A (5). The structures of these compounds were determined on the basis of their spectroscopic and physical data. The anti-HCMV (human cytomegalovirus) activity of 1–5 and their cytotoxicity against selected cell lines were evaluated. Compound 2 exhibited inhibitory activity against HCMV, with an EC50 value of 6.0 μg/mL.
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Chen, W.-H.; Wang, S.-K.; Duh, C.-Y. Polyhydroxylated Steroids from the Bamboo Coral Isis hippuris. Mar. Drugs 2011, 9, 1829-1839.View more citation formats
Chen W-H, Wang S-K, Duh C-Y. Polyhydroxylated Steroids from the Bamboo Coral Isis hippuris. Marine Drugs. 2011; 9(10):1829-1839.Chicago/Turabian Style
Chen, Wei-Hua; Wang, Shang-Kwei; Duh, Chang-Yih. 2011. "Polyhydroxylated Steroids from the Bamboo Coral Isis hippuris." Mar. Drugs 9, no. 10: 1829-1839.