Mar. Drugs 2010, 8(9), 2493-2516; doi:10.3390/md8092493
Review

N-Acetylglucosamine: Production and Applications

1,†email, 2,†email and 3,* email
Received: 22 March 2010; in revised form: 19 April 2010 / Accepted: 23 April 2010 / Published: 15 September 2010
(This article belongs to the Special Issue Marine Chitin and Chitosan)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin, the second most abundant carbohydrate after cellulose. In addition to serving as a component of this homogeneous polysaccharide, GlcNAc is also a basic component of hyaluronic acid and keratin sulfate on the cell surface. In this review, we discuss the industrial production of GlcNAc, using chitin as a substrate, by chemical, enzymatic and biotransformation methods. Also, newly developed methods to obtain GlcNAc using glucose as a substrate in genetically modified microorganisms are introduced. Moreover, GlcNAc has generated interest not only as an underutilized resource but also as a new functional material with high potential in various fields. Here we also take a closer look at the current applications of GlcNAc, and several new and cutting edge approaches in this fascinating area are thoroughly discussed.
Keywords: N-acetylglucosamine; chitin; carbohydrateN-acetylglucosamine; chitin; carbohydrate
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MDPI and ACS Style

Chen, J.-K.; Shen, C.-R.; Liu, C.-L. N-Acetylglucosamine: Production and Applications. Mar. Drugs 2010, 8, 2493-2516.

AMA Style

Chen J-K, Shen C-R, Liu C-L. N-Acetylglucosamine: Production and Applications. Marine Drugs. 2010; 8(9):2493-2516.

Chicago/Turabian Style

Chen, Jeen-Kuan; Shen, Chia-Rui; Liu, Chao-Lin. 2010. "N-Acetylglucosamine: Production and Applications." Mar. Drugs 8, no. 9: 2493-2516.

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