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Chitin Research Revisited
Mar. Drugs 2010, 8(7), 2212-2222; doi:10.3390/md8072212

Preparation and Characterization of Chitosan Poly(acrylic acid) Magnetic Microspheres

2,3,*  and 3
1 Department of radiology, The First Affiliated Hospital of Soochow University, Suzhou 215007, China 2 Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, SIP, Suzhou 215123, China 3 State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, China
* Author to whom correspondence should be addressed.
Received: 16 June 2010 / Revised: 3 July 2010 / Accepted: 7 July 2010 / Published: 23 July 2010
(This article belongs to the Special Issue Marine Chitin and Chitosan)
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Spherical microparticles, capable of responding to magnetic fields, were prepared by encapsulating dextran-coated Fe3O4 nanoparticles into chitosan poly(acrylic acid) (PAA) microspheres template. The obtained magnetic microspheres were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray powder diffraction (XRD), and thermogravimetry (TG). The results showed that the microspheres were formed and demonstrated magnetic behavior in an applied magnetic field. In addition, magnetite particles were well encapsulated and the composite particles have high magnetite content, which was more than 40%.
Keywords: magnetic microsphere; magnetic separation; nanoparticles; chitosan poly(acrylic acid) magnetic microsphere; magnetic separation; nanoparticles; chitosan poly(acrylic acid)
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Guo, L.; Liu, G.; Hong, R.-Y.; Li, H.-Z. Preparation and Characterization of Chitosan Poly(acrylic acid) Magnetic Microspheres. Mar. Drugs 2010, 8, 2212-2222.

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