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Mar. Drugs 2010, 8(7), 2142-2152; doi:10.3390/md8072142
Article

Cytotoxic Cembranes from Indonesian Specimens of the Soft Coral Nephthea sp.

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Received: 19 June 2010; in revised form: 6 July 2010 / Accepted: 9 July 2010 / Published: 13 July 2010
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Abstract: Methanol extracts of two specimens of the soft coral Nephthea sp. collected from the Seribu Islands, Indonesia, were active in an anticancer bioassay. One new (1) and four known diterpenes (25) based on the cembrane carbon skeleton were isolated from these extracts, as was arachidonic acid (8). The structures of all compounds were elucidated using NMR, including 1,1-ADEQUATE and 1D gradient selective NOESY where applicable to determine the relative stereochemistry. Spectroscopic data, including 1H and 13C NMR, UV, IR and optical rotations are reported when enough material was available and where this has not been done previously. Inhibition assays employing three cancer cell lines; SF-268 (CNS), MCF-7 (breast), and H460 (lung) were used to guide the isolation of all compounds.
Keywords: Indonesia; marine natural products; soft coral; Nephthea sp.; anticancer; NMR; cembrane Indonesia; marine natural products; soft coral; Nephthea sp.; anticancer; NMR; cembrane
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Januar, H.I.; Chasanah, E.; Motti, C.A.; Tapiolas, D.M.; Liptrot, C.H.; D. Wright, A. Cytotoxic Cembranes from Indonesian Specimens of the Soft Coral Nephthea sp.. Mar. Drugs 2010, 8, 2142-2152.

AMA Style

Januar HI, Chasanah E, Motti CA, Tapiolas DM, Liptrot CH, D. Wright A. Cytotoxic Cembranes from Indonesian Specimens of the Soft Coral Nephthea sp.. Marine Drugs. 2010; 8(7):2142-2152.

Chicago/Turabian Style

Januar, Hedi Indra; Chasanah, Ekowati; Motti, Cherie A.; Tapiolas, Dianne M.; Liptrot, Catherine H.; D. Wright, Anthony. 2010. "Cytotoxic Cembranes from Indonesian Specimens of the Soft Coral Nephthea sp.." Mar. Drugs 8, no. 7: 2142-2152.



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