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Cytotoxic Cembranes from Indonesian Specimens of the Soft Coral Nephthea sp.
Indonesia Research Center for Marine and Fisheries Product Processing and Biotechnology, Jl. KS Tubun Petamburan VI, Jakarta 10260, Indonesia
Australian Institute of Marine Science, PMB No. 3, Townsville MC, Townsville, 4810, Australia
University of Hawaii, College of Pharmacy, 34 Rainbow Drive, Hilo, HI 96720, USA
Current address: James Cook University, Townsville, QLD 4811, Australia; E-Mail: firstname.lastname@example.org.
* Author to whom correspondence should be addressed.
Received: 19 June 2010; in revised form: 6 July 2010 / Accepted: 9 July 2010 / Published: 13 July 2010
Abstract: Methanol extracts of two specimens of the soft coral Nephthea sp. collected from the Seribu Islands, Indonesia, were active in an anticancer bioassay. One new (1) and four known diterpenes (2–5) based on the cembrane carbon skeleton were isolated from these extracts, as was arachidonic acid (8). The structures of all compounds were elucidated using NMR, including 1,1-ADEQUATE and 1D gradient selective NOESY where applicable to determine the relative stereochemistry. Spectroscopic data, including 1H and 13C NMR, UV, IR and optical rotations are reported when enough material was available and where this has not been done previously. Inhibition assays employing three cancer cell lines; SF-268 (CNS), MCF-7 (breast), and H460 (lung) were used to guide the isolation of all compounds.
Keywords: Indonesia; marine natural products; soft coral; Nephthea sp.; anticancer; NMR; cembrane
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MDPI and ACS Style
Januar, H.I.; Chasanah, E.; Motti, C.A.; Tapiolas, D.M.; Liptrot, C.H.; D. Wright, A. Cytotoxic Cembranes from Indonesian Specimens of the Soft Coral Nephthea sp.. Mar. Drugs 2010, 8, 2142-2152.
Januar HI, Chasanah E, Motti CA, Tapiolas DM, Liptrot CH, D. Wright A. Cytotoxic Cembranes from Indonesian Specimens of the Soft Coral Nephthea sp.. Marine Drugs. 2010; 8(7):2142-2152.
Januar, Hedi Indra; Chasanah, Ekowati; Motti, Cherie A.; Tapiolas, Dianne M.; Liptrot, Catherine H.; D. Wright, Anthony. 2010. "Cytotoxic Cembranes from Indonesian Specimens of the Soft Coral Nephthea sp.." Mar. Drugs 8, no. 7: 2142-2152.