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Mar. Drugs 2010, 8(6), 1763-1768; doi:10.3390/md8061763

Anti-Inflammatory Activity of Chitooligosaccharides in Vivo

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Received: 15 April 2010 / Revised: 14 May 2010 / Accepted: 26 May 2010 / Published: 28 May 2010
(This article belongs to the Special Issue Marine Polysaccharides)
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Abstract: All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatoryactivity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.
Keywords: chitooligosaccharides; anti-inflammatory; animal model chitooligosaccharides; anti-inflammatory; animal model
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fernandes, J.C.; Spindola, H.; De Sousa, V.; Santos-Silva, A.; Pintado, M.E.; Malcata, F.X.; Carvalho, J.E. Anti-Inflammatory Activity of Chitooligosaccharides in Vivo. Mar. Drugs 2010, 8, 1763-1768.

AMA Style

Fernandes JC, Spindola H, De Sousa V, Santos-Silva A, Pintado ME, Malcata FX, Carvalho JE. Anti-Inflammatory Activity of Chitooligosaccharides in Vivo. Marine Drugs. 2010; 8(6):1763-1768.

Chicago/Turabian Style

Fernandes, João C.; Spindola, Humberto; De Sousa, Vanessa; Santos-Silva, Alice; Pintado, Manuela E.; Malcata, Francisco Xavier; Carvalho, João E. 2010. "Anti-Inflammatory Activity of Chitooligosaccharides in Vivo." Mar. Drugs 8, no. 6: 1763-1768.

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