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Anti-Inflammatory Activity of Chitooligosaccharides in Vivo
CBQF/Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Dr. António Bernardino de Almeida, P-4200-072 Porto, Portugal
CPQBA/Divisão de Farmacologia e Toxicologia, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil
Serviço de Bioquímica, Faculdade de Farmácia da Universidade do Porto, Rua Aníbal Cunha, P-4050-047 Porto, Portugal
Instituto de Biologia Molecular e Celular (IBMC) da Universidade do Porto, Rua do Campo Alegre, P-4169-007 Porto, Portugal
* Author to whom correspondence should be addressed.
Received: 15 April 2010; in revised form: 14 May 2010 / Accepted: 26 May 2010 / Published: 28 May 2010
Abstract: All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatoryactivity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.
Keywords: chitooligosaccharides; anti-inflammatory; animal model
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Fernandes, J.C.; Spindola, H.; De Sousa, V.; Santos-Silva, A.; Pintado, M.E.; Malcata, F.X.; Carvalho, J.E. Anti-Inflammatory Activity of Chitooligosaccharides in Vivo. Mar. Drugs 2010, 8, 1763-1768.
Fernandes JC, Spindola H, De Sousa V, Santos-Silva A, Pintado ME, Malcata FX, Carvalho JE. Anti-Inflammatory Activity of Chitooligosaccharides in Vivo. Marine Drugs. 2010; 8(6):1763-1768.
Fernandes, João C.; Spindola, Humberto; De Sousa, Vanessa; Santos-Silva, Alice; Pintado, Manuela E.; Malcata, Francisco Xavier; Carvalho, João E. 2010. "Anti-Inflammatory Activity of Chitooligosaccharides in Vivo." Mar. Drugs 8, no. 6: 1763-1768.