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Mar. Drugs 2010, 8(6), 1763-1768; doi:10.3390/md8061763

Anti-Inflammatory Activity of Chitooligosaccharides in Vivo

1,* , 2
1 CBQF/Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Rua Dr. António Bernardino de Almeida, P-4200-072 Porto, Portugal 2 CPQBA/Divisão de Farmacologia e Toxicologia, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil 3 Serviço de Bioquímica, Faculdade de Farmácia da Universidade do Porto, Rua Aníbal Cunha, P-4050-047 Porto, Portugal 4 Instituto de Biologia Molecular e Celular (IBMC) da Universidade do Porto, Rua do Campo Alegre, P-4169-007 Porto, Portugal
* Author to whom correspondence should be addressed.
Received: 15 April 2010 / Revised: 14 May 2010 / Accepted: 26 May 2010 / Published: 28 May 2010
(This article belongs to the collection Marine Polysaccharides)
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All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatoryactivity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.
Keywords: chitooligosaccharides; anti-inflammatory; animal model chitooligosaccharides; anti-inflammatory; animal model
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fernandes, J.C.; Spindola, H.; De Sousa, V.; Santos-Silva, A.; Pintado, M.E.; Malcata, F.X.; Carvalho, J.E. Anti-Inflammatory Activity of Chitooligosaccharides in Vivo. Mar. Drugs 2010, 8, 1763-1768.

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