Abstract: All the reports to date on the anti-inflammatory activity of chitooligosaccharides (COS) are mostly based on in vitro methods. In this work, the anti-inflammatory activity of two COS mixtures is characterized in vivo (using balb/c mice), following the carrageenan-induced paw edema method. This is a widely accepted animal model of acute inflammation to evaluate the anti-inflammatory effect of drugs. Our data suggest that COS possess anti-inflammatoryactivity, which is dependent on dose and, at higher doses, also on the molecular weight. A single dose of 500 mg/kg b.w. weight may be suitable to treat acute inflammation cases; however, further studies are needed to ascertain the effect upon longer inflammation periods as well as studies upon the bioavailability of these compounds.
This is an open access article distributed under the
Creative Commons Attribution License which permits unrestricted use, distribution,
and reproduction in any medium, provided the original work is properly cited.
Export to BibTeX
MDPI and ACS Style
Fernandes, J.C.; Spindola, H.; De Sousa, V.; Santos-Silva, A.; Pintado, M.E.; Malcata, F.X.; Carvalho, J.E. Anti-Inflammatory Activity of Chitooligosaccharides in Vivo. Mar. Drugs 2010, 8, 1763-1768.
Fernandes JC, Spindola H, De Sousa V, Santos-Silva A, Pintado ME, Malcata FX, Carvalho JE. Anti-Inflammatory Activity of Chitooligosaccharides in Vivo. Marine Drugs. 2010; 8(6):1763-1768.
Fernandes, João C.; Spindola, Humberto; De Sousa, Vanessa; Santos-Silva, Alice; Pintado, Manuela E.; Malcata, Francisco Xavier; Carvalho, João E. 2010. "Anti-Inflammatory Activity of Chitooligosaccharides in Vivo." Mar. Drugs 8, no. 6: 1763-1768.