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Mar. Drugs 2010, 8(4), 1213-1262; doi:10.3390/md8041213
Review

Conventional and Unconventional Antimicrobials from Fish, Marine Invertebrates and Micro-algae

1,* , 2 and 3
Received: 8 February 2010 / Revised: 2 April 2010 / Accepted: 12 April 2010 / Published: 14 April 2010
(This article belongs to the Special Issue Marine Anti-infective Agents)
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Abstract

All eukaryotic organisms, single-celled or multi-cellular, produce a diverse array of natural anti-infective agents that, in addition to conventional antimicrobial peptides, also include proteins and other molecules often not regarded as part of the innate defences. Examples range from histones, fatty acids, and other structural components of cells to pigments and regulatory proteins. These probably represent very ancient defence factors that have been re-used in new ways during evolution. This review discusses the nature, biological role in host protection and potential biotechnological uses of some of these compounds, focusing on those from fish, marine invertebrates and marine micro-algae.
Keywords: amphipathicity; antimicrobial peptides; fatty acids; innate defence; pigments amphipathicity; antimicrobial peptides; fatty acids; innate defence; pigments
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Smith, V.J.; Desbois, A.P.; Dyrynda, E.A. Conventional and Unconventional Antimicrobials from Fish, Marine Invertebrates and Micro-algae. Mar. Drugs 2010, 8, 1213-1262.

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