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Mar. Drugs 2009, 7(4), 528-538; doi:10.3390/md7040528
Article

Lyngbyastatins 8–10, Elastase Inhibitors with Cyclic Depsipeptide Scaffolds Isolated from the Marine Cyanobacterium Lyngbya semiplena

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Received: 19 August 2009 / Revised: 3 October 2009 / Accepted: 28 October 2009 / Published: 3 November 2009
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Abstract

Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8–10 (1–3). The structures of 1–3 were determined by NMR, MS, ESIMS fragmentation and chemical degradation. Compounds 1–3 are closely related to lyngbyastatins 4–7. Like the latter compounds, we found 1–3 to inhibit porcine pancreatic elastase, with IC50 values of 123 nM, 210 nM and 120 nM, respectively.
Keywords: lyngbyastatins; cyanobacteria; Lyngbya semiplena; cyclic depsipeptides; elastase inhibitors lyngbyastatins; cyanobacteria; Lyngbya semiplena; cyclic depsipeptides; elastase inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kwan, J.C.; Taori, K.; Paul, V.J.; Luesch, H. Lyngbyastatins 8–10, Elastase Inhibitors with Cyclic Depsipeptide Scaffolds Isolated from the Marine Cyanobacterium Lyngbya semiplena. Mar. Drugs 2009, 7, 528-538.

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