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Mar. Drugs 2009, 7(4), 528-538; doi:10.3390/md7040528

Lyngbyastatins 8–10, Elastase Inhibitors with Cyclic Depsipeptide Scaffolds Isolated from the Marine Cyanobacterium Lyngbya semiplena

1
Department of Medicinal Chemistry, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610; USA
2
Smithsonian Marine Station, 701 Seaway Drive, Fort Pierce, FL 34949, USA
*
Author to whom correspondence should be addressed.
Received: 19 August 2009 / Revised: 3 October 2009 / Accepted: 28 October 2009 / Published: 3 November 2009
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Abstract

Investigation of an extract from the marine cyanobacterium Lyngbya semiplena, collected in Tumon Bay, Guam, led to the identification of three new cyclodepsipeptides, lyngbyastatins 8–10 (1–3). The structures of 1–3 were determined by NMR, MS, ESIMS fragmentation and chemical degradation. Compounds 1–3 are closely related to lyngbyastatins 4–7. Like the latter compounds, we found 1–3 to inhibit porcine pancreatic elastase, with IC50 values of 123 nM, 210 nM and 120 nM, respectively. View Full-Text
Keywords: lyngbyastatins; cyanobacteria; Lyngbya semiplena; cyclic depsipeptides; elastase inhibitors lyngbyastatins; cyanobacteria; Lyngbya semiplena; cyclic depsipeptides; elastase inhibitors
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MDPI and ACS Style

Kwan, J.C.; Taori, K.; Paul, V.J.; Luesch, H. Lyngbyastatins 8–10, Elastase Inhibitors with Cyclic Depsipeptide Scaffolds Isolated from the Marine Cyanobacterium Lyngbya semiplena. Mar. Drugs 2009, 7, 528-538.

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