Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum

doi:10.3390/md7030472

This article is

freely available
re-usable

Mar. Drugs 2009, 7(3), 472-482; doi:10.3390/md7030472

Article

Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum

Ping-Jyun Sung ^1,2,3^,* , Bo-Yuan Chen ^1,2 , Mei-Ru Lin ^2,3 , Tsong-Long Hwang ⁴ , Wei-Hsien Wang ^2,3 , Jyh-Horng Sheu ³ and Yang-Chang Wu ⁵^,*

¹ Graduate Institute of Marine Biotechnology and Department of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Checheng, Pingtung 944, Taiwan ² National Museum of Marine Biology & Aquarium, Checheng, Pingtung 944, Taiwan ³ Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan ⁴ Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan ⁵ Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan

* Authors to whom correspondence should be addressed.

Received: 26 August 2009; in revised form: 19 September 2009 / Accepted: 23 September 2009 / Published: 23 September 2009

Download PDF Full-Text [141 KB, uploaded 23 September 2009 06:48 CET]

Abstract: Two new briarane-related diterpenoids, designated as excavatoids E (1) andF (2), were isolated from the cultured octocoral Briareum excavatum. The structures ofcompounds 1 and 2 were established on the basis of extensive spectral data analysis. Briaranes 1 and 2 were found to exhibit moderate inhibitory effects on elastase release by human neutrophils.

Keywords: excavatoid; briarane; octocoral; Briareum excavatum; human neutrophil

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Sung, P.-J.; Chen, B.-Y.; Lin, M.-R.; Hwang, T.-L.; Wang, W.-H.; Sheu, J.-H.; Wu, Y.-C. Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum. Mar. Drugs 2009, 7, 472-482.

AMA Style

Sung P.-J., Chen B.-Y., Lin M.-R., Hwang T.-L., Wang W.-H., Sheu J.-H., Wu Y.-C. Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum. Marine Drugs. 2009; 7(3):472-482.

Chicago/Turabian Style

Sung, Ping-Jyun; Chen, Bo-Yuan; Lin, Mei-Ru; Hwang, Tsong-Long; Wang, Wei-Hsien; Sheu, Jyh-Horng; Wu, Yang-Chang. 2009. "Excavatoids E and F: Discovery of Two New Briaranes from the Cultured Octocoral Briareum excavatum." Mar. Drugs 7, no. 3: 472-482.

Mar. Drugs EISSN 1660-3397 Published by MDPI Publishing, Basel, Switzerland RSS E-Mail Table of Contents Alert