Next Article in Journal
The Mauve Stinger Pelagia noctiluca (Forsskål, 1775). Distribution, Ecology, Toxicity and Epidemiology of Stings.
Previous Article in Journal
Smenospongine, a Sesquiterpene Aminoquinone from a Marine Sponge, Induces G1 Arrest or Apoptosis in Different Leukemia Cells
Mar. Drugs 2008, 6(3), 489-495; doi:10.3390/md6030489
Article

Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection

1
, 2,3
, 2, 1,* , 2
 and 2,*
1 Fitoplancton Tóxico, Instituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36080 Vigo and Instituto Español de Oceanografía, Centro Oceanográfico de Vigo (IEO), Cabo Estay, 36200 Vigo, Spain 2 Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna, Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain 3 Departamento de Ingeniería Química y Tecnología Farmacéutica; Universidad de La Laguna; Av. Astrofísico Francisco Sánchez 1, 38071, La Laguna, Tenerife, Spain
* Authors to whom correspondence should be addressed.
Received: 9 July 2008 / Revised: 10 August 2008 / Accepted: 26 August 2008 / Published: 28 August 2008
View Full-Text   |   Download PDF [305 KB, uploaded 24 February 2015]   |   Browse Figures

Abstract

Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, the OA isomer 19-epi-okadaic acid (2) (19-epi-OA), isolated from cultures of Prorocentrum belizeanum, by determining its retention time (RT) and fragmentation pattern using liquid chromatography coupled with mass spectrometry (LC–MS/MS).
Keywords: Marine toxins; DSP; 19-epi-okadaic acid; Prorocentrum belizeanum; LC-MS Marine toxins; DSP; 19-epi-okadaic acid; Prorocentrum belizeanum; LC-MS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Paz, B.; Daranas, A.H.; Cruz, P.G.; Franco, J.M.; Norte, M.; Fernández, J.J. Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection. Mar. Drugs 2008, 6, 489-495.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert