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Mar. Drugs 2008, 6(3), 489-495; doi:10.3390/md6030489
Article

Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection

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Received: 9 July 2008 / Revised: 10 August 2008 / Accepted: 26 August 2008 / Published: 28 August 2008
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Abstract

Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, the OA isomer 19-epi-okadaic acid (2) (19-epi-OA), isolated from cultures of Prorocentrum belizeanum, by determining its retention time (RT) and fragmentation pattern using liquid chromatography coupled with mass spectrometry (LC–MS/MS).
Keywords: Marine toxins; DSP; 19-epi-okadaic acid; Prorocentrum belizeanum; LC-MS Marine toxins; DSP; 19-epi-okadaic acid; Prorocentrum belizeanum; LC-MS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Paz, B.; Daranas, A.H.; Cruz, P.G.; Franco, J.M.; Norte, M.; Fernández, J.J. Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection. Mar. Drugs 2008, 6, 489-495.

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