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Mar. Drugs 2007, 5(4), 168-179; doi:10.3390/md504168

Report on the First Detection of Pectenotoxin-2, Spirolide-A and Their Derivatives in French Shellfish

IFREMER, Microbiology and Phycotoxins Department, BP 21105, 44311 Nantes, France
IFREMER, station d’Arcachon, Quai du Cdt Silhouette, 33120, Arcachon, France
IFREMER, station de Sète, Avenue Jean Monnet, BP 171, 34203, Sète, France
Author to whom correspondence should be addressed.
Received: 16 October 2007 / Accepted: 21 November 2007 / Published: 23 November 2007
(This article belongs to the Special Issue Marine Toxins)
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In the context of the French Phytoplankton and Phycotoxins MonitoringNetwork (REPHY) programme, shellfish samples were harvested from different locationswhere harmful algae blooms were known to have occurred. For all shellfish samples foundpositive by the mouse bioassay for diarrhetic shellfish poisoning (DSP) toxins, liquidchromatography (LC) coupled with mass spectrometry (MS) was used to search for thefollowing lipophilic toxins: okadaic acid (OA), dinophysistoxins (DTXs), pectenotoxins(PTXs), azaspiracids (AZAs), yessotoxins (YTXs), spirolides (SPXs) and gymnodimines(GYMs). In order to investigate the presence of acyl-OAs and/or acyl-DTX-1,-2 (DTX-3),alkaline hydrolysis was performed on all samples, and LC/MS analyses were carried out onthe samples before and after hydrolysis. The results revealed different lipophilic toxinprofiles as a function of the shellfish sampling location. The primary finding was that all ofthe samples contained OA and acyl-OA. In addition, other lipophilic toxins were found inshellfish samples: DTX-2, acyl-DTX-2 and SPXs (SPX-A, SPX-desMeC) on the Atlanticcoast (Southern Brittany, Arcachon), and pectenotoxins (PTX-2, PTX-2-seco-acid and 7-epi-PTX-2-seco-acid) on the Mediterranean coast (Thau lagoon, the island of Corsica).This paper reports on the first detection of PTX-2, SPX-A and their derivatives in Frenchshellfish.
Keywords: DSP toxins; spirolides; pectenotoxins; LC/MS analysis DSP toxins; spirolides; pectenotoxins; LC/MS analysis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Amzil, Z.; Sibat, M.; Royer, F.; Masson, N.; Abadie, E. Report on the First Detection of Pectenotoxin-2, Spirolide-A and Their Derivatives in French Shellfish. Mar. Drugs 2007, 5, 168-179.

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