Mar. Drugs 2006, 4(3), 143-156; doi:10.3390/md403143
Review

The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels

1,2 and 1,* email
Received: 22 November 2005; Accepted: 24 February 2006 / Published: 6 April 2006
(This article belongs to the Special Issue Marine Drugs and Ion Channels)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent work reveals a novel site for tetrodotoxin resistance in the P-region of domain IV.
Keywords: neurotoxin; TTX; NaV; inward sodium current; voltage clamp
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MDPI and ACS Style

Geffeney, S.L.; Ruben, C. The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels. Mar. Drugs 2006, 4, 143-156.

AMA Style

Geffeney SL, Ruben C. The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels. Marine Drugs. 2006; 4(3):143-156.

Chicago/Turabian Style

Geffeney, Shana L.; Ruben, C. 2006. "The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels." Mar. Drugs 4, no. 3: 143-156.

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