Mar. Drugs 2006, 4(3), 143-156; doi:10.3390/md403143
Review

The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels

1 Department of Biology, Utah State University, 5305 Old Main Hill, Logan, Utah, 84322-5305, USA 2 Present address: Department of Molecular and Cellular Physiology, Stanford University, 279 Campus Drive, Beckman Center B115, Stanford, California, 94305, USA
* Author to whom correspondence should be addressed.
Received: 22 November 2005; Accepted: 24 February 2006 / Published: 6 April 2006
(This article belongs to the Special Issue Marine Drugs and Ion Channels)
PDF Full-text Download PDF Full-Text [90 KB, uploaded 28 August 2008 16:06 CEST]
Abstract: Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent work reveals a novel site for tetrodotoxin resistance in the P-region of domain IV.
Keywords: neurotoxin; TTX; NaV; inward sodium current; voltage clamp

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Geffeney, S.L.; Ruben, C. The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels. Mar. Drugs 2006, 4, 143-156.

AMA Style

Geffeney SL, Ruben C. The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels. Marine Drugs. 2006; 4(3):143-156.

Chicago/Turabian Style

Geffeney, Shana L.; Ruben, C. 2006. "The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels." Mar. Drugs 4, no. 3: 143-156.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert