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Mar. Drugs 2006, 4(3), 143-156; doi:10.3390/md403143
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The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels

1,2 and 1,*
1 Department of Biology, Utah State University, 5305 Old Main Hill, Logan, Utah, 84322-5305, USA 2 Present address: Department of Molecular and Cellular Physiology, Stanford University, 279 Campus Drive, Beckman Center B115, Stanford, California, 94305, USA
* Author to whom correspondence should be addressed.
Received: 22 November 2005 / Accepted: 24 February 2006 / Published: 6 April 2006
(This article belongs to the Special Issue Marine Drugs and Ion Channels)
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Abstract

Tetrodotoxin (TTX) is a highly specific blocker of voltage-gated sodium channels. The dissociation constant of block varies with different channel isoforms. Until recently, channel resistance was thought to be primarily imparted by amino acid substitutions at a single position in domain I. Recent work reveals a novel site for tetrodotoxin resistance in the P-region of domain IV.
Keywords: neurotoxin; TTX; NaV; inward sodium current; voltage clamp neurotoxin; TTX; NaV; inward sodium current; voltage clamp
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Geffeney, S.L.; Ruben, C. The Structural Basis and Functional Consequences of Interactions Between Tetrodotoxin and Voltage-Gated Sodium Channels. Mar. Drugs 2006, 4, 143-156.

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