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Mar. Drugs 2006, 4(2), 28-36; doi:10.3390/md402028

Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources

1
Department of Pharmaceutical Sciences, South Dakota State University, Box 2202C, Brookings, SD 57007, USA
2
Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA
3
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan
4
Department of Molecular Biochemistry, Kyoto Prefectural University of Medicine, Kawaramachidori, Kamigyo-Ku, Kyoto 602-0841, Japan
5
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS 38677-1848, USA
6
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
*
Authors to whom correspondence should be addressed.
Received: 7 March 2006 / Accepted: 21 March 2006 / Published: 24 March 2006
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Abstract

In the course of our continuing research in development and evaluation of novel skin cancer chemopreventive agents from marine sources, five semi-synthetic cembranoids derived from the marine natural product sarcophine, isolated from the soft coral Sarcophyton glaucum, were synthesized and shown to exhibit a remarkable chemopreventive activity in the in-vitro Epstein Barr Virus Early Antigen (EBV-EA) activation assay. These compounds were assayed in vivo using the two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator, and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter by topical administration. They showed potent inhibition of both percentage incidence of skin tumor as well asthe multiplicity of skin tumors per mouse compared to untreated controls.Semi-synthetic Cembranoids from Marine Sources View Full-Text
Keywords: Cancer chemoprevention; Skin cancer; Cembranoids; Sarcophine; Sarcophyton glaucum Cancer chemoprevention; Skin cancer; Cembranoids; Sarcophine; Sarcophyton glaucum
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Fahmy, H.; Zjawiony, J.K.; Konoshima, T.; Tokuda, H.; Khan, S.; Khalifa, S. Potent Skin Cancer Chemopreventing Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources. Mar. Drugs 2006, 4, 28-36.

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