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Mar. Drugs 2005, 3(2), 29-35; doi:10.3390/md302029

Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale

Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
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Received: 28 April 2005 / Accepted: 25 May 2005 / Published: 1 June 2005
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Abstract

A new oxazole-containing proteasome inhibitor, secomycalolide A, together with known mycalolide A and 30-hydroxymycalolide A, was isolated from a marine sponge of the genus Mycale. They showed proteasome inhibitory activities with IC50 values of 11-45 μg/mL. View Full-Text
Keywords: proteasome inhibitor; secomycalolide A; mycalolide A; marine sponge; Mycale proteasome inhibitor; secomycalolide A; mycalolide A; marine sponge; Mycale
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Tsukamoto, S.; Koimaru, K.; Ohta, T. Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale. Mar. Drugs 2005, 3, 29-35.

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