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Mar. Drugs 2005, 3(2), 29-35; doi:10.3390/md302029
Article

Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale

* ,  and
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
* Author to whom correspondence should be addressed.
Received: 28 April 2005 / Accepted: 25 May 2005 / Published: 1 June 2005
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Abstract

A new oxazole-containing proteasome inhibitor, secomycalolide A, together with known mycalolide A and 30-hydroxymycalolide A, was isolated from a marine sponge of the genus Mycale. They showed proteasome inhibitory activities with IC50 values of 11-45 μg/mL.
Keywords: proteasome inhibitor; secomycalolide A; mycalolide A; marine sponge; Mycale proteasome inhibitor; secomycalolide A; mycalolide A; marine sponge; Mycale
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Tsukamoto, S.; Koimaru, K.; Ohta, T. Secomycalolide A: A New Proteasome Inhibitor Isolated from a Marine Sponge of the Genus Mycale. Mar. Drugs 2005, 3, 29-35.

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