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Mar. Drugs 2005, 3(2), 22-28; doi:10.3390/md302022
Article

New Cytotoxic and Antibacterial Compounds Isolated from the Sea Hare, Aplysia kurodai

* ,  and
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
* Author to whom correspondence should be addressed.
Received: 31 January 2005 / Accepted: 15 April 2005 / Published: 16 April 2005
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Abstract

The extract of the sea hare, Aplysia kurodai, showed cytotoxicity against HeLa cells and antibacterial activity against Staphylococcus aureus. Bioassay-guided purification afforded four active compounds, which were identified to be laurinterol, laurinterol acetate, debromolaurinterol, and debromolaurinterol acetate by spectroscopic analysis. Although the acetates were derived from laurinterol and debromolaurinterol before, this is the first isolation of the acetates from natural sources.
Keywords: cytotoxicity; antibacterial activity; laurinterol acetate; debromolaurinterol acetate; sea hare; Aplysia kurodai cytotoxicity; antibacterial activity; laurinterol acetate; debromolaurinterol acetate; sea hare; Aplysia kurodai
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Tsukamoto, S.; Yamashita, Y.; Ohta, T. New Cytotoxic and Antibacterial Compounds Isolated from the Sea Hare, Aplysia kurodai. Mar. Drugs 2005, 3, 22-28.

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