Next Article in Journal
Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells
Previous Article in Journal
Isolation of Araguspongine M, a New Stereoisomer of an Araguspongine/Xestospongin alkaloid, and Dopamine from the Marine Sponge Neopetrosia exigua Collected in Palau
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2004, 2(4), 164-169; https://doi.org/10.3390/md204164

Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species

1
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan
2
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba 260-0856, Japan
*
Author to whom correspondence should be addressed.
Received: 17 July 2004 / Accepted: 30 August 2004 / Published: 25 November 2004
View Full-Text   |   Download PDF [59 KB, uploaded 24 February 2015]

Abstract

Two new cytotoxic twelve-membered macrolides, sporiolides A (1) and B (2), were isolated from the cultured broth of a fungus Cladosporium sp., which was separated from an Okinawan marine brown alga Actinotrichia fragilis, and the structures were elucidated by spectroscopic data. Sporiolides A (1) and B (2) exhibited cytotoxicity against murine lymphoma L1210 cells. Spoliolide A (1) showed antifungal activity against Cryptococcus neoformans and Neurospora crassa. View Full-Text
Keywords: marine-derived fungus; Cladosporium sp.; macrolide; cytotoxic marine-derived fungus; Cladosporium sp.; macrolide; cytotoxic
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Shigemori, H.; Kasai, Y.; Komatsu, K.; Tsuda, M.; Mikami, Y.; Kobayashi, J. Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species. Mar. Drugs 2004, 2, 164-169.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top