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Mar. Drugs 2004, 2(4), 164-169; doi:10.3390/md204164
Article

Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species

1, 1, 1, 1, 2 and 1,*
1 Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan 2 Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba 260-0856, Japan
* Author to whom correspondence should be addressed.
Received: 17 July 2004 / Accepted: 30 August 2004 / Published: 25 November 2004
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Abstract

Two new cytotoxic twelve-membered macrolides, sporiolides A (1) and B (2), were isolated from the cultured broth of a fungus Cladosporium sp., which was separated from an Okinawan marine brown alga Actinotrichia fragilis, and the structures were elucidated by spectroscopic data. Sporiolides A (1) and B (2) exhibited cytotoxicity against murine lymphoma L1210 cells. Spoliolide A (1) showed antifungal activity against Cryptococcus neoformans and Neurospora crassa.
Keywords: marine-derived fungus; Cladosporium sp.; macrolide; cytotoxic marine-derived fungus; Cladosporium sp.; macrolide; cytotoxic
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Shigemori, H.; Kasai, Y.; Komatsu, K.; Tsuda, M.; Mikami, Y.; Kobayashi, J. Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species. Mar. Drugs 2004, 2, 164-169.

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