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• Shigemori, H
• Kasai, Y
• Komatsu, K
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• Mikami, Y
• Kobayashi, J
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• Kasai, Y
• Komatsu, K
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Mar. Drugs 2004, 2(4), 164-169; doi:10.3390/md204164

Article

Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species

Hideyuki Shigemori ¹ , Yuu Kasai ¹ , Kazusei Komatsu ¹ , Masashi Tsuda ¹ , Yuzuru Mikami ²  and Jun’ichi Kobayashi ^1,*

¹ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan ² Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba 260-0856, Japan

* Author to whom correspondence should be addressed.

Received: 17 July 2004 / Accepted: 30 August 2004 / Published: 25 November 2004

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Abstract: Two new cytotoxic twelve-membered macrolides, sporiolides A (1) and B (2), were isolated from the cultured broth of a fungus Cladosporium sp., which was separated from an Okinawan marine brown alga Actinotrichia fragilis, and the structures were elucidated by spectroscopic data. Sporiolides A (1) and B (2) exhibited cytotoxicity against murine lymphoma L1210 cells. Spoliolide A (1) showed antifungal activity against Cryptococcus neoformans and Neurospora crassa.

Keywords: marine-derived fungus; Cladosporium sp.; macrolide; cytotoxic

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