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Mar. Drugs 2004, 2(4), 164-169; doi:10.3390/md204164
Article

Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species

1, 1, 1, 1, 2 and 1,*
Received: 17 July 2004 / Accepted: 30 August 2004 / Published: 25 November 2004
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Abstract

Two new cytotoxic twelve-membered macrolides, sporiolides A (1) and B (2), were isolated from the cultured broth of a fungus Cladosporium sp., which was separated from an Okinawan marine brown alga Actinotrichia fragilis, and the structures were elucidated by spectroscopic data. Sporiolides A (1) and B (2) exhibited cytotoxicity against murine lymphoma L1210 cells. Spoliolide A (1) showed antifungal activity against Cryptococcus neoformans and Neurospora crassa.
Keywords: marine-derived fungus; Cladosporium sp.; macrolide; cytotoxic marine-derived fungus; Cladosporium sp.; macrolide; cytotoxic
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shigemori, H.; Kasai, Y.; Komatsu, K.; Tsuda, M.; Mikami, Y.; Kobayashi, J. Sporiolides A and B, New Cytotoxic Twelve-Membered Macrolides from a Marine-Derived Fungus Cladosporium Species. Mar. Drugs 2004, 2, 164-169.

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