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Mar. Drugs, Volume 2, Issue 3 (September 2004) – 6 articles , Pages 83-153

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70 KiB  
Article
Antimicrobial Activity of Untenospongin B, a Metabolite from the Marine Sponge Hippospongia communis collected from the Atlantic Coast of Morocco
by Saida Rifai, Aziz Fassouane Fassouane, Anake Kijjoa and Rob Van Soest
Mar. Drugs 2004, 2(3), 147-153; https://doi.org/10.3390/md203147 - 25 Aug 2004
Cited by 29 | Viewed by 10105
Abstract
(-)-Untenospongin B isolated from the marine sponge Hippospongia communis has been tested for its antimicrobial activity against bacteria and human pathogenic fungi using agar disk method and was found to possess a broad and strong activity toward the test organisms. Its antifungal activity [...] Read more.
(-)-Untenospongin B isolated from the marine sponge Hippospongia communis has been tested for its antimicrobial activity against bacteria and human pathogenic fungi using agar disk method and was found to possess a broad and strong activity toward the test organisms. Its antifungal activity was further characterized by determination of the minimum inhibitory concentration (MIC) against five fungal species using broth microdilution method. Full article
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121 KiB  
Review
Biomedical Compounds from Marine organisms
by Rajeev Kumar Jha and Xu Zi-rong
Mar. Drugs 2004, 2(3), 123-146; https://doi.org/10.3390/md203123 - 25 Aug 2004
Cited by 259 | Viewed by 26095
Abstract
The Ocean, which is called the ‘mother of origin of life’, is also the source of structurally unique natural products that are mainly accumulated in living organisms. Several of these compounds show pharmacological activities and are helpful for the invention and discovery of [...] Read more.
The Ocean, which is called the ‘mother of origin of life’, is also the source of structurally unique natural products that are mainly accumulated in living organisms. Several of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immuno-deficiency syndrome (AIDS), arthritis, etc., while other compounds have been developed as analgesics or to treat inflammation, etc. The lifesaving drugs are mainly found abundantly in microorganisms, algae and invertebrates, while they are scarce in vertebrates. Modern technologies have opened vast areas of research for the extraction of biomedical compounds from oceans and seas. Full article
124 KiB  
Article
Healing and Preventive Effects of Calcium Alginate on Carbon Tetrachloride Induced Liver Injury in Rats
by Yuri S. Khotimchenko and Maxim Y. Khotimchenko
Mar. Drugs 2004, 2(3), 108-122; https://doi.org/10.3390/md203108 - 25 Aug 2004
Cited by 15 | Viewed by 8611
Abstract
The purpose of this study was to investigate the pharmacological effects of calcium alginate on carbon tetrachloride (CCL4)-induced hepatotoxicity in rats. The study included two experiments. In the first experiment the animals were given daily CCL4 through gavage for 7 [...] Read more.
The purpose of this study was to investigate the pharmacological effects of calcium alginate on carbon tetrachloride (CCL4)-induced hepatotoxicity in rats. The study included two experiments. In the first experiment the animals were given daily CCL4 through gavage for 7 days and then 10, 50, or 250 mg/kg b.w. of calcium alginate for 21 days. The increased bilirubin level, enhanced alanine and aspartate aminotransferase activity in plasma and reduced liver glycogen content induced by CCL4 were partly normalized by alginate administration in a dose-dependent manner. In addition, alginate significantly improved CCL4-induced alterations of pro-oxidant and antioxidant biochemical parameters in liver and plasma compared to those of rats administered CCL4. In the second experiment the animals were given daily 10, 50 or 250 mg/kg b.w. of calcium alginate for 21 days before 7-day administration of CCL4. Pretreatment with alginate before CCL4 administration resulted in significantly inhibited increase of the blood enzymatic activities of alanine and aspartate aminotransferases and bilirubin level in a dose-dependent manner. Also, preliminary administration of alginate prevented elevation of lipid peroxidation products and reduction of liver glutathione content in rats given CCL4. These results suggest that calcium alginate exerts healing and preventive effects on CCL4-induced hepatotoxicity in rats. Full article
46 KiB  
Article
Bioactive Chromodorolide Diterpenes from an Aplysillid Sponge
by Wimolpun Rungprom, Warinthorn Chavasiri, Udom Kokpol, Andrew Kotze and Mary J. Garson
Mar. Drugs 2004, 2(3), 101-107; https://doi.org/10.3390/md203101 - 25 Aug 2004
Cited by 21 | Viewed by 8008
Abstract
The known chromodorolides A (1) and B (2), and a new derivative chromodorolide C (3) have been isolated from an Australian sponge and characterized by 1D and 2D NMR experiments. The chromodorolides exhibited significant cytotoxicity against the P388 mouse leukaemia cell line, and [...] Read more.
The known chromodorolides A (1) and B (2), and a new derivative chromodorolide C (3) have been isolated from an Australian sponge and characterized by 1D and 2D NMR experiments. The chromodorolides exhibited significant cytotoxicity against the P388 mouse leukaemia cell line, and also showed activity against the freeliving larval stages of the parasitic nematodes Haemonchus contortus and Trichostrongylus colubriformis. Full article
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179 KiB  
Article
New Alkaloids from the Mediterranean Sponge Hamigera hamigera
by Wafaa Hassan, RuAngelie Edrada, Rainer Ebel, Victor Wray and Peter Proksch
Mar. Drugs 2004, 2(3), 88-100; https://doi.org/10.3390/md203088 - 25 Aug 2004
Cited by 20 | Viewed by 9078
Abstract
The Mediterranean sponge Hamigera hamigera (family Anchinoideae) was studied since its total extract showed deterrent activity in a fish feeding assay. Eight compounds were isolated from the biologically active fractions and four of these proved to be new natural products, hamigeroxalamic acid (1), [...] Read more.
The Mediterranean sponge Hamigera hamigera (family Anchinoideae) was studied since its total extract showed deterrent activity in a fish feeding assay. Eight compounds were isolated from the biologically active fractions and four of these proved to be new natural products, hamigeroxalamic acid (1), hamigeramine (2), hamigeramide (3) and hamiguanosinol (5). The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry . Full article
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56 KiB  
Article
Amphidinolide C2, New Macrolide from Marine Dinoflagellate Amphidinium Species
by Takaaki Kubota, Yusuke Sakuma, Masashi Tsuda and Jun’ichi Kobayashi
Mar. Drugs 2004, 2(3), 83-87; https://doi.org/10.3390/md203083 - 25 Aug 2004
Cited by 34 | Viewed by 8906
Abstract
A new cytotoxic 25-membered macrolide, amphidinolide C2 (1), has been isolated from marine dinoflagellate Amphidinium sp. (Y-71 strain), and the structure 1 was elucidated on the basis of spectroscopic data and chemical means. Full article
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