New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation
AbstractNew thiazole nortopsentin analogues were conveniently synthesized and evaluated for their activity as inhibitors of biofilm formation of relevant Gram-positive and Gram-negative pathogens. All compounds were able to interfere with the first step of biofilm formation in a dose-dependent manner, showing a selectivity against the staphylococcal strains. The most active derivatives elicited IC50 values against Staphylococcus aureus ATCC 25923, ranging from 0.40–2.03 µM. The new compounds showed a typical anti-virulence profile, being able to inhibit the biofilm formation without affecting the microbial growth in the planktonic form. View Full-Text
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Carbone, A.; Parrino, B.; Cusimano, M.G.; Spanò, V.; Montalbano, A.; Barraja, P.; Schillaci, D.; Cirrincione, G.; Diana, P.; Cascioferro, S. New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation. Mar. Drugs 2018, 16, 274.
Carbone A, Parrino B, Cusimano MG, Spanò V, Montalbano A, Barraja P, Schillaci D, Cirrincione G, Diana P, Cascioferro S. New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation. Marine Drugs. 2018; 16(8):274.Chicago/Turabian Style
Carbone, Anna; Parrino, Barbara; Cusimano, Maria G.; Spanò, Virginia; Montalbano, Alessandra; Barraja, Paola; Schillaci, Domenico; Cirrincione, Girolamo; Diana, Patrizia; Cascioferro, Stella. 2018. "New Thiazole Nortopsentin Analogues Inhibit Bacterial Biofilm Formation." Mar. Drugs 16, no. 8: 274.
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