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Mar. Drugs 2018, 16(7), 219; https://doi.org/10.3390/md16070219

A Hetero-Photoautotrophic Two-Stage Cultivation Process for Production of Fucoxanthin by the Marine Diatom Nitzschia laevis

1,2
,
1,2
,
1,2
,
3
,
1,2,3,* and 1,2,*
1
Institute for Food & Bioresource Engineering, College of Engineering, Peking University, Beijing 100871, China
2
BIC-ESAT, College of Engineering, Peking University, Beijing 100871, China
3
Institute for Advanced Study, Shenzhen University, Shenzhen 518060, China
*
Authors to whom correspondence should be addressed.
Received: 25 May 2018 / Revised: 18 June 2018 / Accepted: 22 June 2018 / Published: 25 June 2018
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Abstract

There is currently much interest in fucoxanthin due to its broad beneficial health effects. The major commercial source of fucoxanthin is marine seaweed, which has many shortcomings, and has thus restricted its large-scale production and more diversified applications. In this study, growth characteristics and fucoxanthin accumulation were evaluated to explore the potential of the marine diatom Nitzschia laevis in fucoxanthin production. The results suggested that heterotrophic culture was more effective for cell growth, while the mixotrophic culture was favorable for fucoxanthin accumulation. A two-stage culture strategy was consequently established. A model of exponential fed-batch culture led to a biomass concentration of 17.25 g/L. A mix of white and blue light significantly increased fucoxanthin content. These outcomes were translated into a superior fucoxanthin productivity of 16.5 mg/(L·d), which was more than 2-fold of the best value reported thus far. The culture method established herein therefore represents a promising strategy to boost fucoxanthin production in N. laevis, which might prove to be a valuable natural source of commercial fucoxanthin. View Full-Text
Keywords: microalgae; diatom; Nitzschia laevis; fucoxanthin; fed-batch; mixed lights microalgae; diatom; Nitzschia laevis; fucoxanthin; fed-batch; mixed lights
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lu, X.; Sun, H.; Zhao, W.; Cheng, K.-W.; Chen, F.; Liu, B. A Hetero-Photoautotrophic Two-Stage Cultivation Process for Production of Fucoxanthin by the Marine Diatom Nitzschia laevis. Mar. Drugs 2018, 16, 219.

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