A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp. TJ403-1
AbstractMarine-derived fungi are a promising and untapped reservoir for discovering structurally interesting and pharmacologically active natural products. In our efforts to identify novel bioactive compounds from marine-derived fungi, four breviane spiroditerpenoids, including a new compound, brevione O (1), and three known compounds breviones I (2), J (3), and H (4), together with a known diketopiperazine alkaloid brevicompanine G (5), were isolated and identified from an ethyl acetate extract of the fermented rice substrate of the coral-derived fungus Penicillium sp. TJ403-1. The absolute structure of 1 was elucidated by HRESIMS, one- and two-dimensional NMR spectroscopic data, and a comparison of its electronic circular dichroism (ECD) spectrum with the literature. Moreover, we confirmed the absolute configuration of 5 by single-crystal X-ray crystallography. All the isolated compounds were evaluated for isocitrate dehydrogenase 1 (IDH1) inhibitory activity and cytotoxicity, and compound 2 showed significant inhibitory activities against HL-60, A-549, and HEP3B tumor cell lines with IC50 values of 4.92 ± 0.65, 8.60 ± 1.36, and 5.50 ± 0.67 µM, respectively. View Full-Text
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Yang, B.; Sun, W.; Wang, J.; Lin, S.; Li, X.-N.; Zhu, H.; Luo, Z.; Xue, Y.; Hu, Z.; Zhang, Y. A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp. TJ403-1. Mar. Drugs 2018, 16, 110.
Yang B, Sun W, Wang J, Lin S, Li X-N, Zhu H, Luo Z, Xue Y, Hu Z, Zhang Y. A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp. TJ403-1. Marine Drugs. 2018; 16(4):110.Chicago/Turabian Style
Yang, Beiye; Sun, Weiguang; Wang, Jianping; Lin, Shuang; Li, Xiao-Nian; Zhu, Hucheng; Luo, Zengwei; Xue, Yongbo; Hu, Zhengxi; Zhang, Yonghui. 2018. "A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp. TJ403-1." Mar. Drugs 16, no. 4: 110.
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