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Mar. Drugs 2018, 16(4), 110; https://doi.org/10.3390/md16040110

A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp. TJ403-1

1
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 5 March 2018 / Revised: 23 March 2018 / Accepted: 28 March 2018 / Published: 29 March 2018
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Abstract

Marine-derived fungi are a promising and untapped reservoir for discovering structurally interesting and pharmacologically active natural products. In our efforts to identify novel bioactive compounds from marine-derived fungi, four breviane spiroditerpenoids, including a new compound, brevione O (1), and three known compounds breviones I (2), J (3), and H (4), together with a known diketopiperazine alkaloid brevicompanine G (5), were isolated and identified from an ethyl acetate extract of the fermented rice substrate of the coral-derived fungus Penicillium sp. TJ403-1. The absolute structure of 1 was elucidated by HRESIMS, one- and two-dimensional NMR spectroscopic data, and a comparison of its electronic circular dichroism (ECD) spectrum with the literature. Moreover, we confirmed the absolute configuration of 5 by single-crystal X-ray crystallography. All the isolated compounds were evaluated for isocitrate dehydrogenase 1 (IDH1) inhibitory activity and cytotoxicity, and compound 2 showed significant inhibitory activities against HL-60, A-549, and HEP3B tumor cell lines with IC50 values of 4.92 ± 0.65, 8.60 ± 1.36, and 5.50 ± 0.67 µM, respectively. View Full-Text
Keywords: marine-derived fungi; Penicillium sp. TJ403-1; breviane spiroditerpenoid; IDH1 inhibitory activity; cytotoxicity marine-derived fungi; Penicillium sp. TJ403-1; breviane spiroditerpenoid; IDH1 inhibitory activity; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yang, B.; Sun, W.; Wang, J.; Lin, S.; Li, X.-N.; Zhu, H.; Luo, Z.; Xue, Y.; Hu, Z.; Zhang, Y. A New Breviane Spiroditerpenoid from the Marine-Derived Fungus Penicillium sp. TJ403-1. Mar. Drugs 2018, 16, 110.

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