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Open AccessCommunication
Mar. Drugs 2018, 16(3), 90; https://doi.org/10.3390/md16030090

New Naphthoquinone Terpenoids from Marine Actinobacterium, Streptomyces sp. CNQ-509

Natural Constituents Research Center, Korea Institute of Science and Technology (KIST), Gangneung, Gangwon-do 25451, Korea
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Received: 30 January 2018 / Revised: 8 March 2018 / Accepted: 9 March 2018 / Published: 12 March 2018
(This article belongs to the Special Issue Natural Products from Marine Actinomycetes)
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Abstract

A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivatives (1 and 2) comprised of naphthoquinone and geranyl moieties along with the known terpenoid, debromomarinone. The two-dimensional structure of these compounds was determined through spectral data analysis using data from NMR, MS and UV spectroscopy. Furthermore, the full structures of 1 and 2 including absolute configurations were unequivocally established by a combination of NMR experiments and chemical modifications. View Full-Text
Keywords: marine Actinobacteria; natural product; hybrid terpenoid; meroterpenoid marine Actinobacteria; natural product; hybrid terpenoid; meroterpenoid
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Park, J.-S.; Kwon, H.C. New Naphthoquinone Terpenoids from Marine Actinobacterium, Streptomyces sp. CNQ-509. Mar. Drugs 2018, 16, 90.

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