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Mar. Drugs 2018, 16(2), 74; https://doi.org/10.3390/md16020074

Tetrocarcin Q, a New Spirotetronate with a Unique Glycosyl Group from a Marine-Derived Actinomycete Micromonospora carbonacea LS276

State Key Laboratory of Bioactive Substance and Function of Natural Medicines; Key Laboratory of Biosynthesis of Natural Products of National Health and Family Planning Commission, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xian Nong Tan Street, Beijing 100050, China
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Received: 7 December 2017 / Revised: 7 February 2018 / Accepted: 12 February 2018 / Published: 24 February 2018
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
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Abstract

A new spirotetronate glycoside tetrocarcin Q (1) and six known analogues tetrocarcin A (2), AC6H (3), tetrocarcin N (4), tetrocarcin H (5), arisostatin A (6), and tetrocarcin F1 (7) were isolated from the fermentation broth of the marine-derived actinomycete Micromonospora carbonacea LS276. Their chemical structures were established on the basis of 1D- and 2D-NMR spectroscopy, as well as HR-ESI-MS analysis. The absolute configurations of their stereogenic carbons were determined by circular dichroism (CD) analysis. Compound 1 possesses 2-deoxy-allose, which is a unique sugar type at the C-9 position. This type has not been found in the previously reported spirotetronate glycosides. Compound 1 displayed moderate antibacterial activity against Bacillus subitlis ATCC 63501 with minimum inhibitory concentration (MIC) value of 12.5 μM. View Full-Text
Keywords: marine-derived actinomycete; Micromonospora; spirotetronate glycoside; antibiotic; antibacterial activity marine-derived actinomycete; Micromonospora; spirotetronate glycoside; antibiotic; antibacterial activity
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Gong, T.; Zhen, X.; Li, X.-L.; Chen, J.-J.; Chen, T.-J.; Yang, J.-L.; Zhu, P. Tetrocarcin Q, a New Spirotetronate with a Unique Glycosyl Group from a Marine-Derived Actinomycete Micromonospora carbonacea LS276. Mar. Drugs 2018, 16, 74.

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