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Mar. Drugs 2018, 16(1), 1; doi:10.3390/md16010001

The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation

1
NTT Institute of Hi-Technology, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
2
Department of Marine Life Science, College of Ocean Science and Technology, Korea Maritime and Ocean University, Busan 606-791, Korea
3
School of Pharmacy, the University of Queensland, Brisbane QLD 4072, Australia
4
Faculty of Natural Sciences, Thu Dau Mot University, Thu Dau Mot City 820000, Binh Duong Province, Vietnam
5
Food and Safety Research Center, National Fisheries Research & Development, Busan 46083, Korea
6
Department of Science and Technology, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam
7
Faculty of Chemistry, University of Science-VNU-HCM City, 227 Nguyen Van Cu Street, Ho Chi Minh City 700000, Vietnam
8
Department of Biochemistry, Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City 700000, Vietnam
*
Authors to whom correspondence should be addressed.
Received: 14 October 2017 / Revised: 12 November 2017 / Accepted: 5 December 2017 / Published: 4 January 2018
(This article belongs to the Special Issue Anti-Photoagaing and Photo-Protective Compounds from Marine Organisms)
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Abstract

UV light, especially UVB, is known as a trigger of allergic reaction, leading to mast cell degranulation and histamine release. In this study, phlorotannin Fucofuroeckol-A (F-A) derived from brown algal Ecklonia stolonifera Okamura was evaluated for its protective capability against UVB-induced allergic reaction in RBL-2H3 mast cells. It was revealed that F-A significantly suppress mast cell degranulation via decreasing histamine release as well as intracellular Ca2+ elevation at the concentration of 50 μM. Moreover, the inhibitory effect of F-A on IL-1β and TNF-α productions was also evidenced. Notably, the protective activity of F-A against mast cell degranulation was found due to scavenging ROS production. Accordingly, F-A from brown algal E. stolonifera was suggested to be promising candidate for its protective capability against UVB-induced allergic reaction. View Full-Text
Keywords: Ecklonia stolonifera; phlorotannin; Fucofuroeckol-A; anti-allergy; degranulation; mast cells Ecklonia stolonifera; phlorotannin; Fucofuroeckol-A; anti-allergy; degranulation; mast cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Vo, T.S.; Kim, S.-K.; Ryu, B.; Ngo, D.H.; Yoon, N.-Y.; Bach, L.G.; Hang, N.T.N.; Ngo, D.N. The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation. Mar. Drugs 2018, 16, 1.

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