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Mar. Drugs 2017, 15(7), 234; doi:10.3390/md15070234

Functional Comparison for Lipid Metabolism and Intestinal and Fecal Microflora Enzyme Activities between Low Molecular Weight Chitosan and Chitosan Oligosaccharide in High-Fat-Diet-Fed Rats

1
Department of Cell and Tissue Engineering, Changhua Christian Hospital, Changhua 500, Taiwan
2
Institute of Toxicology, College of Medicine, National Taiwan University, No. 1, Section 1, Jen-Ai Rd., Taipei 100, Taiwan
3
Department of Food Science, College of Life Science, National Taiwan Ocean University, Keelung 202, Taiwan
4
Department of Pediatrics, College of Medicine and Hospital, National Taiwan University, Taipei 100, Taiwan
5
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 5 July 2017 / Revised: 15 July 2017 / Accepted: 19 July 2017 / Published: 24 July 2017
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Abstract

The present study investigated and compared the regulatory effects on the lipid-related metabolism and intestinal disaccharidase/fecal bacterial enzyme activities between low molecular weight chitosan and chitosan oligosaccharide in high-fat-diet-fed rats. Diet supplementation of low molecular weight chitosan showed greater efficiency than chitosan oligosaccharide in suppressing the increased weights in body and in liver and adipose tissues of high-fat-diet-fed rats. Supplementation of low molecular weight chitosan also showed a greater improvement than chitosan oligosaccharide in imbalance of plasma, hepatic, and fecal lipid profiles, and intestinal disaccharidase activities in high-fat-diet-fed rats. Moreover, both low molecular weight chitosan and chitosan oligosaccharide significantly decreased the fecal microflora mucinase and β-glucuronidase activities in high-fat-diet-fed rats. These results suggest that low molecular weight chitosan exerts a greater positive improvement than chitosan oligosaccharide in lipid metabolism and intestinal disaccharidase activity in high-fat-diet-induced obese rats. View Full-Text
Keywords: low molecular weight chitosan; chitosan oligosaccharide; lipid metabolism; fecal mucinase; fecal β-glucuronidase low molecular weight chitosan; chitosan oligosaccharide; lipid metabolism; fecal mucinase; fecal β-glucuronidase
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MDPI and ACS Style

Chiu, C.-Y.; Feng, S.-A.; Liu, S.-H.; Chiang, M.-T. Functional Comparison for Lipid Metabolism and Intestinal and Fecal Microflora Enzyme Activities between Low Molecular Weight Chitosan and Chitosan Oligosaccharide in High-Fat-Diet-Fed Rats. Mar. Drugs 2017, 15, 234.

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