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Mar. Drugs 2017, 15(7), 202; doi:10.3390/md15070202

Isoprenoids from the Soft Coral Sarcophyton glaucum

1
School of Pharmacy, China Medical University, Taichung 404, Taiwan
2
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
3
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
4
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
5
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
6
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
7
Research Center for Natural Products & Drug Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan
8
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
9
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
10
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
11
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
12
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 6 June 2017 / Revised: 16 June 2017 / Accepted: 22 June 2017 / Published: 27 June 2017
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
View Full-Text   |   Download PDF [2119 KB, uploaded 28 June 2017]   |  

Abstract

Five new isoprenoids, 3,4,8,16-tetra-epi-lobocrasol (1), 1,15β-epoxy-deoxysarcophine (2), 3,4-dihydro-4α,7β,8α-trihydroxy-Δ2-sarcophine (3), ent-sarcophyolide E (4), and 16-deacetyl- halicrasterol B (5) and ten known compounds 6‒15, were characterized from the marine soft coral Sarcophyton glaucum, collected off Taitung coastline. Their structures were defined by analyzing spectra data, especially 2D NMR and electronic circular dichroism (ECD). The structure of the known compound lobocrasol (7) was revised. Cytotoxicity potential of the isolated compounds was reported, too. View Full-Text
Keywords: sarcophyton glaucum; lobocrasol; ent-sarcophyolide E; sarcophine sarcophyton glaucum; lobocrasol; ent-sarcophyolide E; sarcophine
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MDPI and ACS Style

Chao, C.-H.; Li, W.-L.; Huang, C.-Y.; Ahmed, A.F.; Dai, C.-F.; Wu, Y.-C.; Lu, M.-C.; Liaw, C.-C.; Sheu, J.-H. Isoprenoids from the Soft Coral Sarcophyton glaucum. Mar. Drugs 2017, 15, 202.

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