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Mar. Drugs 2017, 15(7), 202; doi:10.3390/md15070202

Isoprenoids from the Soft Coral Sarcophyton glaucum

School of Pharmacy, China Medical University, Taichung 404, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Institute of Oceanography, National Taiwan University, Taipei 112, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Research Center for Natural Products & Drug Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan
Frontier Center for Ocean Science and Technology, National Sun Yat-sen University, Kaohsiung 804, Taiwan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 6 June 2017 / Revised: 16 June 2017 / Accepted: 22 June 2017 / Published: 27 June 2017
(This article belongs to the Special Issue Natural Products from Coral Reef Organisms)
View Full-Text   |   Download PDF [2119 KB, uploaded 28 June 2017]   |  


Five new isoprenoids, 3,4,8,16-tetra-epi-lobocrasol (1), 1,15β-epoxy-deoxysarcophine (2), 3,4-dihydro-4α,7β,8α-trihydroxy-Δ2-sarcophine (3), ent-sarcophyolide E (4), and 16-deacetyl- halicrasterol B (5) and ten known compounds 6‒15, were characterized from the marine soft coral Sarcophyton glaucum, collected off Taitung coastline. Their structures were defined by analyzing spectra data, especially 2D NMR and electronic circular dichroism (ECD). The structure of the known compound lobocrasol (7) was revised. Cytotoxicity potential of the isolated compounds was reported, too. View Full-Text
Keywords: sarcophyton glaucum; lobocrasol; ent-sarcophyolide E; sarcophine sarcophyton glaucum; lobocrasol; ent-sarcophyolide E; sarcophine

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chao, C.-H.; Li, W.-L.; Huang, C.-Y.; Ahmed, A.F.; Dai, C.-F.; Wu, Y.-C.; Lu, M.-C.; Liaw, C.-C.; Sheu, J.-H. Isoprenoids from the Soft Coral Sarcophyton glaucum. Mar. Drugs 2017, 15, 202.

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