Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications
AbstractEnzymes play key roles in different cellular processes, for example, in signal transduction, cell differentiation and proliferation, metabolic processes, DNA damage repair, apoptosis, and response to stress. A deregulation of enzymes has been considered one of the first causes of several diseases, including cancers. In the last several years, enzyme inhibitors, being good candidates as drugs in the pathogenic processes, have received an increasing amount of attention for their potential application in pharmacology. The marine environment is considered a challenging source of enzyme inhibitors for pharmacological applications. In this review, we report on secondary metabolites with enzyme inhibitory activity, focusing our attention on marine sponges and bacteria as promising sources. In the case of sponges, we only reported the kinase inhibitors, because this class was the most representative isolated so far from these marine organisms. View Full-Text
Share & Cite This Article
Ruocco, N.; Costantini, S.; Palumbo, F.; Costantini, M. Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications. Mar. Drugs 2017, 15, 173.
Ruocco N, Costantini S, Palumbo F, Costantini M. Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications. Marine Drugs. 2017; 15(6):173.Chicago/Turabian Style
Ruocco, Nadia; Costantini, Susan; Palumbo, Flora; Costantini, Maria. 2017. "Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications." Mar. Drugs 15, no. 6: 173.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.