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Mar. Drugs 2017, 15(6), 146; doi:10.3390/md15060146

Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. (TA07-1)

Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, the Ministry of Education of China, Qingdao 266003, China
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, China
Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China
Author to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Received: 25 March 2017 / Revised: 11 May 2017 / Accepted: 23 May 2017 / Published: 25 May 2017
(This article belongs to the Special Issue Marine Bioactive Natural Product Studies in Asia)
View Full-Text   |   Download PDF [1060 KB, uploaded 25 May 2017]   |  


Three new diphenyl ether derivatives—phomaethers A–C (13) and five known compounds—including a diphenyl ether analog, 2,3′-dihydroxy-4-methoxy-5′,6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)—were isolated from a gorgonian-derived fungus Phoma sp. (TA07-1). Their structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by acid hydrolysis reactions. It was the first report to discover the diphenyl glycoside derivatives from coral-derived fungi. Compounds 1, 3, and 4 showed selective strong antibacterial activity against five pathogenic bacteria with the minimum inhibiting concentration (MIC) values and minimum bactericidal concentration (MBC) values between 0.156 and 10.0 μM. View Full-Text
Keywords: gorgonian-derived fungus; Phoma sp.; diphenyl ether; isocoumarin; antibacterial activity gorgonian-derived fungus; Phoma sp.; diphenyl ether; isocoumarin; antibacterial activity

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Shi, T.; Qi, J.; Shao, C.-L.; Zhao, D.-L.; Hou, X.-M.; Wang, C.-Y. Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp. (TA07-1). Mar. Drugs 2017, 15, 146.

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