Next Article in Journal
Preparation and Characterization of Chitosan Obtained from Shells of Shrimp (Litopenaeus vannamei Boone)
Previous Article in Journal
Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp. AS-79
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle
Mar. Drugs 2017, 15(5), 138;

Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.

College of Pharmacy, Ewha Womans University, Seoul 03760, Korea
Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 03760, Korea
Department of Biology, College of Life Science and Natural Resource, Sunchon National University, Suncheon 57922, Korea
Authors to whom correspondence should be addressed.
Received: 10 January 2017 / Revised: 19 April 2017 / Accepted: 8 May 2017 / Published: 13 May 2017
View Full-Text   |   Download PDF [3315 KB, uploaded 17 May 2017]   |  


Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the murine melanoma cell line, B16F10, and human melanoma cell line, MNT-1, as well as a pigmented 3D-human skin model. (-)-4-Hydroxysattabacin treatment decreased melanin contents in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-stimulated B16F10 cells. Quantitative real time PCR (qRT–PCR) demonstrated that treatment with (-)-4-hydroxysattabacin down-regulated several melanogenic genes, including tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) while their enzymatic activities were unaffected. The anti-melanogenic effects of (-)-4-hydroxysattabacin were further demonstrated in a pigmented 3D human epidermal skin model, MelanodermTM, and manifested as whitening and regression of melanocyte activation in the tissue. View Full-Text
Keywords: Bacillus sp.; (-)-4-hydroxysattabacin; melanogenesis; marine-derived; anti-pigmentary effect Bacillus sp.; (-)-4-hydroxysattabacin; melanogenesis; marine-derived; anti-pigmentary effect

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Kim, K.; Leutou, A.S.; Jeong, H.; Kim, D.; Seong, C.N.; Nam, S.-J.; Lim, K.-M. Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.. Mar. Drugs 2017, 15, 138.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top