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Mar. Drugs 2017, 15(5), 138; doi:10.3390/md15050138

Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.

1
College of Pharmacy, Ewha Womans University, Seoul 03760, Korea
2
Department of Chemistry and Nano Science, Global Top 5 Program, Ewha Womans University, Seoul 03760, Korea
3
Department of Biology, College of Life Science and Natural Resource, Sunchon National University, Suncheon 57922, Korea
*
Authors to whom correspondence should be addressed.
Received: 10 January 2017 / Revised: 19 April 2017 / Accepted: 8 May 2017 / Published: 13 May 2017
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Abstract

Bioactivity-guided isolation of a crude extract from a culture broth of Bacillus sp. has led to the isolation of (-)-4-hydroxysattabacin (1). The inhibitory effect of (-)-4-hydroxysattabacin (1) was investigated on melanogenesis in the murine melanoma cell line, B16F10, and human melanoma cell line, MNT-1, as well as a pigmented 3D-human skin model. (-)-4-Hydroxysattabacin treatment decreased melanin contents in a dose-dependent manner in α-melanocyte stimulating hormone (α-MSH)-stimulated B16F10 cells. Quantitative real time PCR (qRT–PCR) demonstrated that treatment with (-)-4-hydroxysattabacin down-regulated several melanogenic genes, including tyrosinase, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2) while their enzymatic activities were unaffected. The anti-melanogenic effects of (-)-4-hydroxysattabacin were further demonstrated in a pigmented 3D human epidermal skin model, MelanodermTM, and manifested as whitening and regression of melanocyte activation in the tissue. View Full-Text
Keywords: Bacillus sp.; (-)-4-hydroxysattabacin; melanogenesis; marine-derived; anti-pigmentary effect Bacillus sp.; (-)-4-hydroxysattabacin; melanogenesis; marine-derived; anti-pigmentary effect
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kim, K.; Leutou, A.S.; Jeong, H.; Kim, D.; Seong, C.N.; Nam, S.-J.; Lim, K.-M. Anti-Pigmentary Effect of (-)-4-Hydroxysattabacin from the Marine-Derived Bacterium Bacillus sp.. Mar. Drugs 2017, 15, 138.

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