Next Article in Journal
An Overview of the Protective Effects of Chitosan and Acetylated Chitosan Oligosaccharides against Neuronal Disorders
Previous Article in Journal
An Extract from Shrimp Processing By-Products Protects SH-SY5Y Cells from Neurotoxicity Induced by Aβ25–35
Article Menu
Issue 3 (March) cover image

Export Article

Open AccessArticle
Mar. Drugs 2017, 15(3), 86; doi:10.3390/md15030086

Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL

Institute of Marine Biology, Ocean College, Zhejiang University, Zhoushan Campus, No. 1 Zheda Road, Zhoushan 316021, China
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 22 December 2016 / Revised: 16 March 2017 / Accepted: 17 March 2017 / Published: 22 March 2017
View Full-Text   |   Download PDF [3600 KB, uploaded 24 March 2017]   |  

Abstract

Two prenylated indole alkaloids were isolated from the ethyl acetate extracts of a marine-derived fungus Penicillium sp. NH-SL and one of them exhibited potent cytotoxic activity against mouse hepa 1c1c7 cells. In order to detect other bioactive analogs, we used liquid chromatogram tandem mass spectrometry (LC-MS/MS) to analyze the mass spectrometric characteristics of the isolated compounds as well as the crude extracts. As a result, three other analogs were detected, and their structures were deduced according to the similar fragmentation patterns. This is the first systematic report on the mass spectrometric characteristics of prenylated indole derivatives. View Full-Text
Keywords: prenylated indole alkaloids; Penicillium sp. NH-SL; LC-MS/MS analysis; cytotoxic activity; mass spectrometric characteristics prenylated indole alkaloids; Penicillium sp. NH-SL; LC-MS/MS analysis; cytotoxic activity; mass spectrometric characteristics
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ding, H.; Ding, W.; Ma, Z. Mass Spectrometric Characteristics of Prenylated Indole Derivatives from Marine-Derived Penicillium sp. NH-SL. Mar. Drugs 2017, 15, 86.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top