Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer
AbstractLung cancer is the leading cause of cancer mortality worldwide and non-small-cell lung cancer (NSCLC) is the most common type. Marine plants provide rich resources for anticancer drug discovery. Fucoxanthin (FX), a Laminaria japonica extract, has attracted great research interest for its antitumor activities. Accumulating evidence suggests anti-proliferative effects of FX on many cancer cell lines including NSCLCs, but the detailed mechanisms remain unclear. In the present investigation, we confirmed molecular mechanisms and in vivo anti-lung cancer effect of FX at the first time. Flow cytometry, real-time PCR, western blotting and immunohistochemistry revealed that FX arrested cell cycle and induced apoptosis by modulating expression of p53, p21, Fas, PUMA, Bcl-2 and caspase-3/8. These results show that FX is a potent marine drug for human non-small-cell lung cancer treatment. View Full-Text
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Mei, C.; Zhou, S.; Zhu, L.; Ming, J.; Zeng, F.; Xu, R. Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer. Mar. Drugs 2017, 15, 39.
Mei C, Zhou S, Zhu L, Ming J, Zeng F, Xu R. Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer. Marine Drugs. 2017; 15(2):39.Chicago/Turabian Style
Mei, ChengHan; Zhou, ShunChang; Zhu, Lin; Ming, JiaXiong; Zeng, FanDian; Xu, Rong. 2017. "Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer." Mar. Drugs 15, no. 2: 39.
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