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Open AccessCommunication
Mar. Drugs 2016, 14(5), 88; doi:10.3390/md14050088

4-Hydroxy-2,3-Dimethyl-2-Nonen-4-Olide Has an Inhibitory Effect on Pro-Inflammatory Cytokine Production in CpG-Stimulated Bone Marrow-Derived Dendritic Cells

1
School of Medicine and Brain Korea 21 PLUS Program, Jeju National University, Jeju 690-756, Korea
2
Institute of Medical Science, Jeju National University, Jeju 690-756, Korea
3
Department of Chemistry and Cosmetics, College of Natural Sciences, Jeju National University, Jeju 690-756, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Received: 28 January 2016 / Revised: 5 April 2016 / Accepted: 28 April 2016 / Published: 4 May 2016
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Abstract

This study was intended to assess the anti-inflammatory properties of 4-hydroxy-2,3-dimethyl-2-nonen-4-olide (Comp) isolated from Ulva pertusa Kjellman on production of pro-inflammatory cytokines. Comp revealed remarkable inhibitory effects on production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs). Comp pre-treatment in the CpG DNA-stimulated BMDCs exhibited strong inhibition of interleukin (IL)-12 p40 and IL-6 production with IC50 values ranging from 7.57 ± 0.2 to 10.83 ± 0.3, respectively. It revealed an inhibitory effect on the phosphorylation of ERK1/2, JNK1/2, and p38, and on activator protein (AP)-1 reporter activity. Comp displayed noteworthy inhibitory effects on phosphorylation and degradation of IκBα, and on NF-κB reporter activity. In summary, these data propose that Comp has substantial anti-inflammatory properties and warrants further study concerning its potential use as a therapeutic agent for inflammation-associated maladies. View Full-Text
Keywords: 4-hydroxy-2,3-dimethyl-2-nonen-4-olide; inflammation; activator protein-1; pro-inflammatory cytokine 4-hydroxy-2,3-dimethyl-2-nonen-4-olide; inflammation; activator protein-1; pro-inflammatory cytokine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Manzoor, Z.; Koo, J.-E.; Ali, I.; Kim, J.-E.; Byeon, S.-H.; Yoo, E.-S.; Kang, H.-K.; Hyun, J.-W.; Lee, N.-H.; Koh, Y.-S. 4-Hydroxy-2,3-Dimethyl-2-Nonen-4-Olide Has an Inhibitory Effect on Pro-Inflammatory Cytokine Production in CpG-Stimulated Bone Marrow-Derived Dendritic Cells. Mar. Drugs 2016, 14, 88.

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