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Mar. Drugs 2016, 14(11), 216; doi:10.3390/md14110216

Alkynyl-Containing Peptides of Marine Origin: A Review

1,2,†
,
3,†
,
1,* and 1,*
1
Research Center for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
2
School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, China
3
Department of Pharmacy, Graduate School, Hunan University of Chinese Medicine, Changsha 410208, China
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Se-Kwon Kim
Received: 19 September 2016 / Revised: 15 November 2016 / Accepted: 16 November 2016 / Published: 23 November 2016
(This article belongs to the Special Issue Marine Proteins and Peptides)
View Full-Text   |   Download PDF [2217 KB, uploaded 23 November 2016]   |  

Abstract

Since the 1990s, a number of terminal alkynyl residue-containing cyclic/acyclic peptides have been identified from marine organisms, especially cyanobacteria and marine mollusks. This review has presented 66 peptides, which covers over 90% marine peptides with terminal alkynyl fatty acyl units. In fact, more than 90% of these peptides described in the literature are of cyanobacterial origin. Interestingly, all the linear peptides featured with terminal alkyne were solely discovered from marine cyanobacteria. The objective of this article is to provide an overview on the types, structural characterization of these unusual terminal alkynyl fatty acyl units, as well as the sources and biological functions of their composed peptides. Many of these peptides have a variety of biological activities, including antitumor, antibacterial, antimalarial, etc. Further, we have also discussed the evident biosynthetic origin responsible for formation of terminal alkynes of natural PKS (polyketide synthase)/NRPS (nonribosome peptide synthetase) hybrids. View Full-Text
Keywords: marine cyanobacteria; mollusk; alkynyl peptides; biological activity; absolute configuration marine cyanobacteria; mollusk; alkynyl peptides; biological activity; absolute configuration
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Chai, Q.-Y.; Yang, Z.; Lin, H.-W.; Han, B.-N. Alkynyl-Containing Peptides of Marine Origin: A Review. Mar. Drugs 2016, 14, 216.

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