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Mar. Drugs 2016, 14(11), 212; doi:10.3390/md14110212

Anti-Melanogenic Activity of Gagunin D, a Highly Oxygenated Diterpenoid from the Marine Sponge Phorbas sp., via Modulating Tyrosinase Expression and Degradation

College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea
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Author to whom correspondence should be addressed.
Academic Editor: Kirsten Benkendorff
Received: 10 October 2016 / Revised: 10 November 2016 / Accepted: 14 November 2016 / Published: 17 November 2016
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
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Abstract

Tyrosinase is the rate-limiting enzyme critical for melanin synthesis and controls pigmentation in the skin. The inhibition of tyrosinase is currently the most common approach for the development of skin-whitening cosmetics. Gagunin D (GD), a highly oxygenated diterpenoid isolated from the marine sponge Phorbas sp., has exhibited cytotoxicity toward human leukemia cells. However, the effect of GD on normal cells and the molecular mechanisms remain to be elucidated. In the present study, we identified for the first time the anti-melanogenic activity of GD and its precise underlying mechanisms in mouse melan-a cells. GD significantly inhibited melanin synthesis in the melan-a cells and a reconstructed human skin model. Further analysis revealed that GD suppressed the expression of tyrosinase and increased the rate of tyrosinase degradation. GD also inhibited tyrosinase enzymatic activity. In addition, GD effectively suppressed the expression of proteins associated with melanosome transfer. These findings suggest that GD is a potential candidate for cosmetic formulations due to its multi-functional properties. View Full-Text
Keywords: Gagunin D; melanogenesis; tyrosinase; melan-a Gagunin D; melanogenesis; tyrosinase; melan-a
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MDPI and ACS Style

Lee, H.Y.; Jang, E.J.; Bae, S.Y.; Jeon, J.-E.; Park, H.J.; Shin, J.; Lee, S.K. Anti-Melanogenic Activity of Gagunin D, a Highly Oxygenated Diterpenoid from the Marine Sponge Phorbas sp., via Modulating Tyrosinase Expression and Degradation. Mar. Drugs 2016, 14, 212.

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