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Mar. Drugs 2016, 14(10), 189; doi:10.3390/md14100189

Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus

1,2,†
,
2,†
and
1,3,*
1
School of Medicine, Tongji University, 1239 Siping Road, Shanghai 200092, China
2
College of Food Science and Technology, Shanghai Ocean University, 999 Huchenghuan Road, Shanghai 201306, China
3
Ocean College, Zhejiang University, 1 Zheda Road, Zhoushan 316021, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Kirsten Benkendorff
Received: 14 August 2016 / Revised: 9 October 2016 / Accepted: 11 October 2016 / Published: 19 October 2016
(This article belongs to the Collection Bioactive Compounds from Marine Invertebrates)
View Full-Text   |   Download PDF [811 KB, uploaded 19 October 2016]   |  

Abstract

Three new polyhydroxysteroidal glycosides, hesperuside A (1), B (2), and C (3), as well as a known novaeguinoside A (4), were isolated from the ethanol extract of starfish Craspidaster hesperus collected from the South China Sea. Their structures were elucidated by extensive spectroscopic methods and chemical evidence. The compounds 13 present unprecedented carbohydrate chain 3-O-methyl-β-d-galactopyranose, which differ from each other in the side chains. These compounds exhibited cytotoxicity against human tumor cells BEL-7402, MOLT-4, and A-549 in vitro. View Full-Text
Keywords: starfish Craspidaster hesperus; polyhydroxysteroidal glycoside; cytotoxicity; tumor starfish Craspidaster hesperus; polyhydroxysteroidal glycoside; cytotoxicity; tumor
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Kang, J.-X.; Kang, Y.-F.; Han, H. Three New Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Craspidaster hesperus. Mar. Drugs 2016, 14, 189.

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