A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66
AbstractThe wblAso gene functions as a global regulatory gene in a negative manner in deepsea-derived Streptomyces somaliensis SCSIO ZH66. A new dioic acid (1) as well as two known butenolides (2 and 3) were isolated from the ΔwblAso mutant strain of S. somaliensis SCSIO ZH66. The structure of 1 was elucidated by a combination of spectroscopic analyses, including MS and NMR techniques. In the cell growth inhibitory evaluation, compound 3 exhibited moderate activity against the human hepatic carcinoma cell line (Huh7.5) with an IC50 value of 19.4 μg/mL, while compounds 1 and 2 showed null activity up to 100 μg/mL. View Full-Text
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Huang, H.; Li, H.; Qiu, Y.; Hou, L.; Ju, J.; Li, W. A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66. Mar. Drugs 2016, 14, 184.
Huang H, Li H, Qiu Y, Hou L, Ju J, Li W. A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66. Marine Drugs. 2016; 14(10):184.Chicago/Turabian Style
Huang, Huiming; Li, Huayue; Qiu, Yanhong; Hou, Lukuan; Ju, Jianhua; Li, Wenli. 2016. "A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66." Mar. Drugs 14, no. 10: 184.
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