Next Article in Journal
Specific Metabolites in a Phaeodactylum tricornutum Strain Isolated from Western Norwegian Fjord Water
Next Article in Special Issue
Cyanobacterial Metabolite Calothrixins: Recent Advances in Synthesis and Biological Evaluation
Previous Article in Journal
Determination of FVIIa-sTF Inhibitors in Toxic Microcystis Cyanobacteria by LC-MS Technique
Previous Article in Special Issue
Isolation and Synthesis of Laxaphycin B-Type Peptides: A Case Study and Clues to Their Biosynthesis
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2016, 14(1), 8; doi:10.3390/md14010008

Structures and Activity of New Anabaenopeptins Produced by Baltic Sea Cyanobacteria

1
Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6 A, 20520 Turku, Finland
2
Department of Marine Biotechnology, University of Gdańsk, Al. Marszałka Piłsudskiego 46, 81-378 Gdynia, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 22 October 2015 / Revised: 22 December 2015 / Accepted: 23 December 2015 / Published: 30 December 2015
(This article belongs to the Special Issue Compounds from Cyanobacteria)
View Full-Text   |   Download PDF [1544 KB, uploaded 31 December 2015]   |  

Abstract

Anabaenopeptins, bioactive cyclic hexapeptides, were isolated by preparative reversed-phase high performance liquid chromatography from an extract of Baltic Sea cyanobacterial bloom material composed of Nodularia spumigena (50%), Aphanizomenon flos-aquae (40%) and Dolichospermum spp. (10%). Five new anabaenopeptins and nine previously known anabaenopeptins were isolated, and their putative structures were determined by tandem mass spectrometry. The activity of the peptides against carboxypeptidase A and protein phosphatase 1 as well as chymotrypsin, trypsin and thrombin was tested. All anabaenopeptins inhibited carboxypeptidase A (apart from one anabaenopeptin variant) and protein phosphatase 1 with varying potency, but no inhibition against chymotrypsin, trypsin and thrombin was observed. View Full-Text
Keywords: Anabaenopeptins; nodulapeptins; Baltic Sea; cyanobacteria; Nodularia spumigena; Aphanizomenon flos-aquae; Dolichospermum spp.; carboxypeptidase A; protein phosphatase 1 Anabaenopeptins; nodulapeptins; Baltic Sea; cyanobacteria; Nodularia spumigena; Aphanizomenon flos-aquae; Dolichospermum spp.; carboxypeptidase A; protein phosphatase 1
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Spoof, L.; Błaszczyk, A.; Meriluoto, J.; Cegłowska, M.; Mazur-Marzec, H. Structures and Activity of New Anabaenopeptins Produced by Baltic Sea Cyanobacteria. Mar. Drugs 2016, 14, 8.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top