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Mar. Drugs 2016, 14(1), 5; doi:10.3390/md14010005

New Drugs from Marine Organisms in Alzheimer’s Disease

1
Clinical and Molecular Epidemiology Division, IRCCS “San RaffaelePisana” Via di Valcannuta, 247, RomeI-00166, Italy
2
Scientific Direction, IRCCS “San RaffaelePisana” Via di Valcannuta, 247, Rome I-00166, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: George Perry
Received: 5 November 2015 / Revised: 9 December 2015 / Accepted: 21 December 2015 / Published: 25 December 2015
(This article belongs to the Special Issue Marine Compounds and Their Application in Neurological Disorders)
View Full-Text   |   Download PDF [903 KB, uploaded 25 December 2015]   |  

Abstract

Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder. Current approved drugs may only ameliorate symptoms in a restricted number of patients and for a restricted period of time. Currently, there is a translational research challenge into identifying the new effective drugs and their respective new therapeutic targets in AD and other neurodegenerative disorders. In this review, selected examples of marine-derived compounds in neurodegeneration, specifically in AD field are reported. The emphasis has been done on compounds and their possible relevant biological activities. The proposed drug development paradigm and current hypotheses should be accurately investigated in the future of AD therapy directions although taking into account successful examples of such approach represented by Cytarabine, Trabectedin, Eribulin and Ziconotide. We review a complexity of the translational research for such a development of new therapies for AD. Bryostatin is a prominent candidate for the therapy of AD and other types of dementia in humans. View Full-Text
Keywords: marine drugs; Alzheimer’s disease; mechanisms of activity; clinical/preclinical studies; bryostatin; new drugs marine drugs; Alzheimer’s disease; mechanisms of activity; clinical/preclinical studies; bryostatin; new drugs
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Russo, P.; Kisialiou, A.; Lamonaca, P.; Moroni, R.; Prinzi, G.; Fini, M. New Drugs from Marine Organisms in Alzheimer’s Disease. Mar. Drugs 2016, 14, 5.

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