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Mar. Drugs 2016, 14(1), 14; doi:10.3390/md14010014

Anti-Inflammatory Activity of Tanzawaic Acid Derivatives from a Marine-Derived Fungus Penicillium steckii 108YD142

1
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 426-744, Korea
2
Department of Applied Chemistry, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-ku, Ansan, Gyeongi-do 15588, Korea
3
Jeju International Marine Science Center for Research & Education, Korea Institute of Ocean Science and Technology, Jeju 63349, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Received: 27 November 2015 / Revised: 22 December 2015 / Accepted: 5 January 2016 / Published: 8 January 2016
View Full-Text   |   Download PDF [1461 KB, uploaded 11 January 2016]   |  

Abstract

Chemical investigation of a marine-derived fungus, Penicillium steckii 108YD142, resulted in the discovery of a new tanzawaic acid derivative, tanzawaic acid Q (1), together with four known analogues, tanzawaic acids A (2), C (3), D (4), and K (5). The structures of tanzawaic acid derivatives 15 were determined by the detailed analysis of 1D, 2D NMR and LC-MS data, along with chemical methods and literature data analysis. These compounds significantly inhibited nitric oxide (NO) production and the new tanzawaic acid Q (1) inhibited the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins and mRNA expressions in RAW 264.7 macrophages. Additionally, compound 1 reduced the mRNA levels of inflammatory cytokines. Taken together, the results of this study demonstrated that the new tanzawaic acid derivative inhibits LPS-induced inflammation. This is the first report on the anti-inflammatory activity of tanzawaic acid Q (1). View Full-Text
Keywords: marine fungus; Penicillium steckii; tanzawaic acids; anti-inflammatory marine fungus; Penicillium steckii; tanzawaic acids; anti-inflammatory
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Shin, H.J.; Pil, G.B.; Heo, S.-J.; Lee, H.-S.; Lee, J.S.; Lee, Y.-J.; Lee, J.; Won, H.S. Anti-Inflammatory Activity of Tanzawaic Acid Derivatives from a Marine-Derived Fungus Penicillium steckii 108YD142. Mar. Drugs 2016, 14, 14.

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