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Mar. Drugs 2016, 14(1), 12; doi:10.3390/md14010012

Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.

1
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
2
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
3
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
4
Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan
5
Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
6
Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
7
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
8
Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
9
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
10
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
11
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
12
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
13
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 12 December 2015 / Revised: 26 December 2015 / Accepted: 4 January 2016 / Published: 7 January 2016
View Full-Text   |   Download PDF [1037 KB, uploaded 7 January 2016]   |  

Abstract

Three new 9,11-secosterols, pinnisterols A–C (13), were isolated from a gorgonian coral Pinnigorgia sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1 and 3 displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1 was found to show moderate cytotoxicity in hepatic stellate cells (HSCs). View Full-Text
Keywords: secosterol; gorgonian; Pinnigorgia; anti-inflammatory; superoxide anion; elastase; cytotoxicity; HSCs secosterol; gorgonian; Pinnigorgia; anti-inflammatory; superoxide anion; elastase; cytotoxicity; HSCs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chang, Y.-C.; Kuo, L.-M.; Hwang, T.-L.; Yeh, J.; Wen, Z.-H.; Fang, L.-S.; Wu, Y.-C.; Lin, C.-S.; Sheu, J.-H.; Sung, P.-J. Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.. Mar. Drugs 2016, 14, 12.

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