Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan
Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Research Center for Industry of Human Ecology and Graduate Institute of Health Industry Technology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Department of Sport, Health, and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
Authors to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 12 December 2015 / Revised: 26 December 2015 / Accepted: 4 January 2016 / Published: 7 January 2016
Three new 9,11-secosterols, pinnisterols A–C (1
), were isolated from a gorgonian coral Pinnigorgia
sp., collected off the waters of Taiwan. The structures of these compounds were elucidated on the basis of spectroscopic methods. The new sterols 1
displayed significant inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils, and sterol 1
was found to show moderate cytotoxicity in hepatic stellate cells (HSCs).
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Chang, Y.-C.; Kuo, L.-M.; Hwang, T.-L.; Yeh, J.; Wen, Z.-H.; Fang, L.-S.; Wu, Y.-C.; Lin, C.-S.; Sheu, J.-H.; Sung, P.-J. Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.. Mar. Drugs 2016, 14, 12.
Chang Y-C, Kuo L-M, Hwang T-L, Yeh J, Wen Z-H, Fang L-S, Wu Y-C, Lin C-S, Sheu J-H, Sung P-J. Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.. Marine Drugs. 2016; 14(1):12.
Chang, Yu-Chia; Kuo, Liang-Mou; Hwang, Tsong-Long; Yeh, Jessica; Wen, Zhi-Hong; Fang, Lee-Shing; Wu, Yang-Chang; Lin, Chan-Shing; Sheu, Jyh-Horng; Sung, Ping-Jyun. 2016. "Pinnisterols A–C, New 9,11-Secosterols from a Gorgonian Pinnigorgia sp.." Mar. Drugs 14, no. 1: 12.
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