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Mar. Drugs 2016, 14(1), 10; doi:10.3390/md14010010

Bioactive Polycyclic Quinones from Marine Streptomyces sp. 182SMLY

1
Ocean College, Zhejiang University, Hangzhou 310058, China
2
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 6 December 2015 / Revised: 21 December 2015 / Accepted: 29 December 2015 / Published: 6 January 2016
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Abstract

Chemical investigation of the cultures of marine Streptomyces sp. 182SMLY led to the discovery of two new polycyclic anthraquinones, which were elucidated as N-acetyl-N-demethylmayamycin (1) and streptoanthraquinone A (2) based on the extensive spectroscopic analysis including 2D NMR, HRESIMS, and an electronic circular dichroism (ECD) calculation. Both anthraquinones remarkably suppressed the proliferation of four different glioma cell lines with IC50 values in a range from 0.5 to 7.3 μM and induced apoptosis in the glioma cells. The ratios of IC50 for normal human astrocytes to IC50 for glioma cells were 6.4–53 for 1 and >14–31 for 2. N-acetyl-N-demethylmayamycin (1) also inhibited the growth of methicillin-resistant Staphylococcus aureus with MIC 20.0 μM. View Full-Text
Keywords: marine bacterium Streptomyces sp. 182SMLY; N-acetyl-N-demethylmayamycin; streptoanthraquinone A; bioactivities against glioma cells and bacteria marine bacterium Streptomyces sp. 182SMLY; N-acetyl-N-demethylmayamycin; streptoanthraquinone A; bioactivities against glioma cells and bacteria
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Liang, Y.; Xie, X.; Chen, L.; Yan, S.; Ye, X.; Anjum, K.; Huang, H.; Lian, X.; Zhang, Z. Bioactive Polycyclic Quinones from Marine Streptomyces sp. 182SMLY. Mar. Drugs 2016, 14, 10.

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