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Mar. Drugs 2015, 13(9), 5552-5563; doi:10.3390/md13095552

Sphingosines Derived from Marine Sponge as Potential Multi-Target Drug Related to Disorders in Cancer Development

1
Laboratório de Farmacognosia, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90610-000, Brazil
2
Centro de Estudos em Estresse Oxidativo, Dpto. Bioquímica, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS 90035-000, Brazil
3
Museu Nacional, Departamento de Invertebrados, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ 20940-040, Brazil
4
Fundação Zoobotânica, Museu de Ciências Naturais, Porto Alegre, RS 90690-000, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Valeria Costantino
Received: 30 May 2015 / Revised: 14 August 2015 / Accepted: 14 August 2015 / Published: 25 August 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
View Full-Text   |   Download PDF [803 KB, uploaded 25 August 2015]   |  

Abstract

Haliclona tubifera, marine sponge species abundant in Brazilian coastline, presents only a few papers published in the literature. Recently, we have reported the isolation of two modified C18 sphingoid bases: (2R,3R,6R,7Z)-2-aminooctadec-7-ene-1,3, 6-triol and and (2R,3R,6R)-2-aminooctadec-1,3,6-triol. In order to continue our research, in this work aimed at the biological investigation of fractions that led to the isolation of these compounds. We evaluated the cytotoxic effect of marine sponge H. tubifera fractions in glioma (U87) and neuroblastoma (SH-SY5Y) human cell lines. In addition, considering the link between cancer, imbalance of reactive oxygen species and coagulation disorders, we also investigated the in vitro effects on blood coagulation and their redox properties. We showed that the ethyl acetate (EtOAc) fraction, rich in sphingoid bases, had important cytotoxic effects in both cancer cell lines with an IC50 < 15 μg/mL and also can inhibit the production of peroxyl radicals. Interestingly, this fraction increased the recalcification time of human blood, showing anticoagulant properties. The present study indicates the sphingosines fraction as a promising source of chemical prototypes, especially multifunctional drugs in cancer therapy. View Full-Text
Keywords: H. tubifera; sphingosines; cytotoxic; anticoagulant; antioxidant H. tubifera; sphingosines; cytotoxic; anticoagulant; antioxidant
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Biegelmeyer, R.; Schröder, R.; Rambo, D.F.; Dresch, R.R.; Carraro, J.L.F.; Mothes, B.; Moreira, J.C.F.; Junior, M.L.C.F.; Henriques, A.T. Sphingosines Derived from Marine Sponge as Potential Multi-Target Drug Related to Disorders in Cancer Development. Mar. Drugs 2015, 13, 5552-5563.

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