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Mar. Drugs 2015, 13(7), 4492-4504; doi:10.3390/md13074492

Identification and Bioactivity of Compounds from the Mangrove Endophytic Fungus Alternaria sp.

College of Materials and Energy (Formerly College of Science), South China Agricultural University, Guangzhou 510642, China
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Academic Editor: Orazio Taglialatela-Scafati
Received: 23 April 2015 / Revised: 8 July 2015 / Accepted: 10 July 2015 / Published: 20 July 2015
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Abstract

Racemic new cyclohexenone and cyclopentenone derivatives, (±)-(4R*,5S*,6S*)-3-amino-4,5,6-trihydroxy-2-methoxy-5-methyl-2-cyclohexen-1-one (1) and (±)-(4S*,5S*)-2,4,5-trihydroxy-3-methoxy-4-methoxycarbonyl-5-methyl-2-cyclopenten-1-one (2), and two new xanthone derivatives 4-chloro-1,5-dihydroxy-3-hydroxymethyl-6-methoxycarbonyl-xanthen-9-one (3) and 2,8-dimethoxy-1,6-dimethoxycarbonyl-xanthen-9-one (4), along with one known compound, fischexanthone (5), were isolated from the culture of the mangrove endophytic fungus Alternaria sp. R6. The structures of these compounds were elucidated by analysis of their MS (Mass), one and two dimensional NMR (nuclear magnetic resonance) spectroscopic data. Compounds 1 and 2 exhibited potent ABTS [2,2′-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid)] scavenging activities with EC50 values of 8.19 ± 0.15 and 16.09 ± 0.01 μM, respectively. In comparison to Triadimefon, compounds 2 and 3 exhibited inhibitory activities against Fusarium graminearum with minimal inhibitory concentration (MIC) values of 215.52 and 107.14 μM, respectively, and compound 3 exhibited antifungal activity against Calletotrichum musae with MIC value of 214.29 μM. View Full-Text
Keywords: Alternaria sp.; secondary metabolites; cyclopentenone; cyclohexenone; xanthone; antioxidant activity; antimicrobial activity Alternaria sp.; secondary metabolites; cyclopentenone; cyclohexenone; xanthone; antioxidant activity; antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wang, J.; Ding, W.; Wang, R.; Du, Y.; Liu, H.; Kong, X.; Li, C. Identification and Bioactivity of Compounds from the Mangrove Endophytic Fungus Alternaria sp.. Mar. Drugs 2015, 13, 4492-4504.

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